Dr Vincent (Vinnie) Fagan
Biography
Dr Vinnie Fagan is an organic and medicinal chemist whose research interests include drug discovery (particularly inhibitors of epigenetic targets), development of new methodologies in drug discovery, and vaccine development (particularly development of better adjuvants). He has moved several times between academic and industrial environments, which has given him broad ranging experience. He joined the MU Chemistry Department in 2024 and is now focused on discovering new disease targets, developing inhibitors for those targets and demonstrating their utility in disease contexts.
- Sep 2024 to present: Assistant Prof, Department of Chemistry, Maynooth University.
- Jul 2023 - Sep 2024: Senior Scientist (sustainable plastics), Addible Ltd, Kildare, Ireland.
- Feb 2022 - Jul 2023: Lecturer, Department of Chemistry, Maynooth University.
- Feb 2020 - Feb 2022: Research Support Officer, Research Development Office, Maynooth University.
- Mar 2016 - Jun 2019: Postdoctoral Research Scientist (small molecule inhibitors of epigenetic targets), University of Oxford, UK.
- Oct 2014 - Dec 2015: Technical Development Chemist, GlaxoSmithKline, Cork, Ireland.
- Jul 2012 - Jun 2014: Postdoctoral Research Fellow (chemical synthesis of subunit vaccines), University of Queensland, Australia.
- Sep 2007 - Oct 2011: PhD (organic & medicinal chemistry), University of Ireland Galway, Ireland.
- Aug 2006 - May 2007: Production Chemist, Johnson Matthey, Cork, Ireland.
- May 2005 - Aug 2005: R&D Analytical Chemist, Boston Scientific, Galway, Ireland.
- May 2003 - Aug 2006: BSc in Chemist, University of Galway, Ireland.
Peer Reviewed Journal
| Year | Publication | |
|---|---|---|
| 2025 | Xiong, Y; Greschik, H; Johansson, C; Seifert, L; Gamble, V; Park, KS; Fagan, V; Li, F; Chau, I; Vedadi, M; Arrowsmith, CH; Brennan, P; Fedorov, O; Jung, M; Farnie, G; Liu, J; Oppermann, U; Schüle, R; Jin, J (2025) 'Discovery of a Potent, Selective, and Cell-Active SPIN1 Inhibitor'. Journal of medicinal chemistry, 67 (7). [DOI] | |
| 2019 | (2019) 'A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin Function'. Medicinal Chemistry, . [DOI] | |
| 2019 | (2019) 'Discovery of a Potent and Selective Fragment-like Inhibitor of Methyllysine Reader Protein Spindlin 1 (SPIN1)'. Medicinal Chemistry, . [DOI] [Full-Text] | |
| 2017 | (2017) 'Synthesis, Characterization and Immunological Evaluation of Self-Adjuvanting Groupâ A Streptococcal Vaccine Candidates Bearing Various Lipidic Adjuvanting Moieties'. Chembiochem : A European Journal Of Chemical Biology, . [DOI] | |
| 2017 | (2017) 'Evaluation of Lipopeptides as Toll-like Receptor 2 Ligands'. Current Drug Delivery, . [DOI] | |
| 2014 | (2014) 'Design, synthesis and characterisation of mannosylated ovalbumin lipid core peptide self-adjuvanting vaccine delivery system'. Drug Delivery and Translational Research, . [DOI] | |
| 2014 | (2014) 'Convergent synthetic methodology for the construction of self-adjuvanting lipopeptide vaccines using a novel carbohydrate scaffold'. Beilstein Journal of Organic Chemistry, . [DOI] | |
| 2012 | (2012) 'COMPARE analysis of the toxicity of an iminoquinone derivative of the imidazo[5,4-f]benzimidazoles with NAD(P)H:quinone oxidoreductase 1 (NQO1) activity and computational docking of quinones as NQO1 substrates'. Bioorganic and Medicinal Chemistry, . [DOI] | |
| 2012 | Fagan, V.; Bonham, S.; McArdle, P.; Carty, M.P.; Aldabbagh, F. (2012) 'Synthesis and toxicity of new ring-fused imidazo[5,4-f] benzimidazolequinones and mechanism using amine N-oxide cyclizations'. European Journal of Organic Chemistry, . [Link] [DOI] | |
| 2010 | (2010) 'One-pot double intramolecular homolytic aromatic substitution routes to dialicyclic ring fused imidazobenzimidazolequinones and preliminary analysis of anticancer activity'. Organic and Biomolecular Chemistry, . [DOI] |
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