Dr Andrew Hogan
Biography
He completed his undergraduate and post-graduate studies in Maynooth University, before being awarded a Newman Fellowship in Obesity with Prof Donal O'Shea in UCD and St Vincent's Hospital.
In 2012, he was awarded a Research Fellowship from the National Children's Research Centre and established the Childhood Obesity Immunology Group. He has also been a research fellow in the lab of Prof Lydia Lynch in Harvard Medical School.
The Obesity Immunology Research group focuses on the impact of Obesity on the immune system and the development of co-morbid diseases such as Type II Diabetes and Cancer.
Currently the group is comprised of 3 Post Doctoral Scientists, 3 PhD Students and 2 MD Students.
The group has strong clinical partnerships with Prof Donal O'Shea & Prof Helen Heneghan (St Vincent's University Hospital), Prof Declan Cody (CHI Crumlin) and Dr Anne Marie Tobin (Tallaght Hospital).
The group is funded by grants from the National Children's Research Centre, Health Research Board, Dublin Skin Hospital & Enterprise Ireland.
Research Interests
Ireland has one of the highest rates of childhood obesity in the world. One in four Irish school-going children are living with overweight or obesity, and as a result these children are at a higher risk of developing cardiovascular, metabolic and cancer related co-morbidities later in life. The purpose of our research is to understand how obesity drives this increased risk and aim to develop successful interventions to prevent the establishment of overt chronic disease.
The Obesity Immunology research programme aims to do this by investigating (1) how obesity impacts the immune system, driving inflammation and dysregulation, which underpins the development of the aforementioned diseases. (2) Our research also focuses on how the immune system regulates metabolism (from insulin signalling to adiposity), better understanding of these processes will allow us to identify new therapeutic strategies for obesity and its associated diseases.
To date we have published >60 peer reviewed papers in leading peer-reviewed journals including Nature Immunology, PNAS, Science Signaling, Obesity and The Journal of Immunology.
Research Projects
Peer Reviewed Journal
Year | Publication | |
---|---|---|
2024 | Eimear K. Ryan,* Christy Clutter,†,‡ Conor De Barra,* Benjamin J. Jenkins,§ Simon O’Shaughnessy,{ Odhra ́n K. Ryan,*,|| Chloe McKenna,* Helen M. Heneghan,|| Fiona Walsh,* David K. Finlay,{,# Linda V. Sinclair,** Nicholas Jones,§ Daniel T. Leung,†,‡ Donal O’Shea,*,|| and Andrew E. Hogan* (2024) 'Iron Is Critical for Mucosal-Associated Invariant T Cell Metabolism and Effector Functions'. Journal of Immunology, . [DOI] | |
2023 | De Barra, C.; Khalil, M.; Mat, A.; O'Donnell, C.; Shaamile, F.; Brennan, K.; O'Shea, D.; Hogan, A.E. (2023) 'Glucagon-like peptide-1 therapy in people with obesity restores natural killer cell metabolism and effector function'. Obesity, . [Link] [DOI] | |
2011 | Hogan A.; O'Reilly V.; Dunne M.; Dere R.; Zeng S.; O'Brien C.; Amu S.; Fallon P.; Exley M.; O'Farrelly C.; Zhu X.; Doherty D. (2011) 'Activation of human invariant natural killer T cells with a thioglycoside analogue of α-galactosylceramide'. Journal of Clinical Immunology, 140 (2):196-207. [DOI] [Full-Text] | |
2018 | Brennan K; O'Leary BD; Mc Laughlin D; Breen EP; Connolly E; Ali N; O'Driscoll DN; Ozaki E; Mahony R; Mulfaul K; Ryan AM; Ni Chianain A; McHugh A; Molloy EJ; Hogan AE; Paran S; McAuliffe FM; Doyle SL; (2018) 'Type 1 IFN Induction by Cytosolic Nucleic Acid Is Intact in Neonatal Mononuclear Cells, Contrasting Starkly with Neonatal Hyporesponsiveness to TLR Ligation Due to Independence from Endosome-Mediated IRF3 Activation'. Journal of Immunology, . [DOI] [Full-Text] | |
2017 | Boulenouar, S; Michelet, X; Duquette, D; Alvarez, D; Hogan, AE; Dold, C; O'Connor, D; Stutte, S; Tavakkoli, A; Winters, D; Exley, MA; O'Shea, D; Brenner, MB; von Andrian, U; Lynch, L (2017) 'Adipose Type One Innate Lymphoid Cells Regulate Macrophage Homeostasis through Targeted Cytotoxicity'. Immunity, 46 :273-286. [DOI] [Full-Text] | |
2017 | Tobin, LM; Mavinkurve, M; Carolan, E; Kinlen, D; O'Brien, EC; Little, MA; Finlay, DK; Cody, D; Hogan, AE; O'Shea, D (2017) 'NK cells in childhood obesity are activated, metabolically stressed, and functionally deficient'. Jci Insight, 2 . [DOI] [Full-Text] | |
2017 | Khan F; Mat A; Hogan A; Kent B; Eigenheer S; Corrigan M; O'Shea D; Butler M; (2017) 'Preliminary asthma -related outcomes following glucagon - like peptide 1 agonist therapy'. QJM - Monthly Journal of the Association of Physicians, . [DOI] [Full-Text] | |
2016 | Lynch, L; Hogan, AE; Duquette, D; Lester, C; Banks, A; LeClair, K; Cohen, DE; Ghosh, A; Lu, B; Corrigan, M; Stevanovic, D; Maratos-Flier, E; Drucker, DJ; O'Shea, D; Brenner, M (2016) 'iNKT Cells Induce FGF21 for Thermogenesis and Are Required for Maximal Weight Loss in GLP1 Therapy'. Cell Metabolism, 24 :510-519. [DOI] [Full-Text] | |
2016 | Hams, E; Bermingham, R; Wurlod, FA; Hogan, AE; O'Shea, D; Preston, RJ; Rodewald, HR; McKenzie, ANJ; Fallon, PG (2016) 'The helminth T2 RNase omega 1 promotes metabolic homeostasis in an IL-33-and group 2 innate lymphoid cell-dependent mechanism'. FASEB Journal, 30 :824-835. [DOI] [Full-Text] | |
2015 | Carolan E.; Tobin L.; Mangan B.; Corrigan M.; Gaoatswe G.; Byrne G.; Geoghegan J.; Cody D.; O'Connell J.; Winter D.; Doherty D.; Lynch L.; O'Shea D.; Hogan A. (2015) 'Altered distribution and increased IL-17 production by mucosal-associated invariant T cells in adult and childhood obesity'. Journal of Immunology, 194 (12):5775-5780. [DOI] [Full-Text] | |
2015 | Gaoatswe, G; Kent, BD; Corrigan, MA; Nolan, G; Hogan, AE; McNicholas, WT; O'Shea, D (2015) 'Invariant Natural Killer T Cell Deficiency and Functional Impairment in Sleep Apnea: Links to Cancer Comorbidity'. Sleep, 38 :1629-1634. [DOI] [Full-Text] | |
2015 | Woods C.; Corrigan M.; Gathercole L.; Taylor A.; Hughes B.; Gaoatswe G.; Manolopoulos K.; Hogan A.; O'Connell J.; Stewart P.; Tomlinson J.; O'Shea D.; Sherlock M. (2015) 'Tissue specific regulation of glucocorticoids in severe obesity and the response to significant weight loss following bariatric surgery (BARICORT)'. Journal of Clinical Endocrinology and Metabolism, 100 (4):1434-1444. [DOI] [Full-Text] | |
2014 | Yang, S; Wang, BW; Humphries, F; Hogan, AE; O'Shea, D; Moynagh, PN (2014) 'The E3 Ubiquitin Ligase Pellino3 Protects against Obesity-Induced Inflammation and Insulin Resistance'. Immunity, 41 :973-987. [DOI] [Full-Text] | |
2014 | Carolan, E; Hogan, AE; Corrigan, M; Gaotswe, G; O'Connell, J; Foley, N; O'Neill, LA; Cody, D; O'Shea, D (2014) 'The Impact of Childhood Obesity on Inflammation, Innate Immune Cell Frequency, and Metabolic MicroRNA Expression'. Journal of Clinical Endocrinology and Metabolism, 99 :474-478. [DOI] [Full-Text] | |
2014 | Hogan, AE; Gaoatswe, G; Lynch, L; Corrigan, MA; Woods, C; O'Connell, J; O'Shea, D (2014) 'Glucagon-like peptide 1 analogue therapy directly modulates innate immune-mediated inflammation in individuals with type 2 diabetes mellitus'. Diabetologia, 57 :781-784. [DOI] [Full-Text] | |
2013 | Mangan B.; Dunne M.; O'Reilly V.; Dunne P.; Exley M.; O'Shea D.; Scotet E.; Hogan A.; Doherty D. (2013) 'Cutting edge: CD1d restriction and Th1/Th2/Th17 cytokine secretion by human Vδ3 T cells'. Journal of Immunology, 191 (1):30-34. [DOI] [Full-Text] | |
2013 | O'Shea D.; Corrigan M.; Dunne M.; Jackson R.; Woods C.; Gaoatswe G.; Moynagh P.; O'Connell J.; Hogan A. (2013) 'Changes in human dendritic cell number and function in severe obesity may contribute to increased susceptibility to viral infection'. International Journal of Obesity, 37 (11):1510-1513. [DOI] [Full-Text] | |
2013 | Zeng, SG; Ghnewa, YG; O'Reilly, VP; Lyons, VG; Atzberger, A; Hogan, AE; Exley, MA; Doherty, DG (2013) 'Human Invariant NKT Cell Subsets Differentially Promote Differentiation, Antibody Production, and T Cell Stimulation by B Cells In Vitro'. Journal of Immunology, 191 :1666-1676. [DOI] [Full-Text] | |
2012 | Lynch L.; Nowak M.; Varghese B.; Clark J.; Hogan A.; Toxavidis V.; Balk S.; O'Shea D.; O'Farrelly C.; Exley M. (2012) 'Adipose Tissue Invariant NKT Cells Protect against Diet-Induced Obesity and Metabolic Disorder through Regulatory Cytokine Production'. Immunity, 37 (3):574-587. [DOI] [Full-Text] | |
2012 | Farah N.; Hogan A.; O'Connor N.; Kennelly M.; O'Shea D.; Turner M. (2012) 'Correlation between maternal inflammatory markers and fetomaternal adiposity'. Cytokine, 60 (1):96-99. [DOI] [Full-Text] | |
2011 | O'Reilly V.; Zeng S.; Bricard G.; Atzberger A.; Hogan A.; Jackson J.; Feighery C.; Porcelli S.; Doherty D. (2011) 'Distinct and overlapping effector functions of expanded human CD4 +, cd8α + and CD4 -CD8α - invariant natural killer T cells'. PLoS ONE, 6 (12). [DOI] [Full-Text] | |
2011 | Hogan, AE; O'Reilly, V; Dunne, MR; Dere, RT; Zeng, SJG; O'Brien, C; Amu, S; Fallon, PG; Exley, MA; O'Farrelly, C; Zhu, XM; Doherty, DG (2011) 'Activation of human invariant natural killer T cells with a thioglycoside analogue of alpha-galactosylceramide'. Journal of Clinical Immunology, 140 :196-207. [DOI] [Full-Text] | |
2011 | Hogan, AE; Tobin, AM; Ahern, T; Corrigan, MA; Gaoatswe, G; Jackson, R; O'Reilly, V; Lynch, L; Doherty, DG; Moynagh, PN; Kirby, B; O'Connell, J; O'Shea, D (2011) 'Glucagon-like peptide-1 (GLP-1) and the regulation of human invariant natural killer T cells: lessons from obesity, diabetes and psoriasis'. Diabetologia, 54 :2745-2754. [DOI] [Full-Text] | |
2011 | Michielsen, AJ; Hogan, AE; Marry, J; Tosetto, M; Cox, F; Hyland, JM; Sheahan, KD; O'Donoghue, DP; Mulcahy, HE; Ryan, EJ; O'Sullivan, JN (2011) 'Tumour Tissue Microenvironment Can Inhibit Dendritic Cell Maturation in Colorectal Cancer'. PLoS ONE, 6 . [DOI] [Full-Text] | |
2011 | Hogan, AE; Corrigan, MA; O'Reilly, V; Gaoatswe, G; O'Connell, J; Doherty, DG; Lynch, L; O'Shea, D (2011) 'Cigarette smoke alters the invariant natural killer T cell function and may inhibit anti-tumor responses'. Journal of Clinical Immunology, 140 :229-235. [DOI] [Full-Text] | |
2023 | Kenny, G.; O’Reilly, S.; Wrigley Kelly, N.; Negi, R.; Gaillard, C.; Alalwan, D.; Saini, G.; Alrawahneh, T.; Francois, N.; Angeliadis, M.; Garcia Leon, A.A.; Tinago, W.; Feeney, E.R.; Cotter, A.G.; de Barra, E.; Yousif, O.; Horgan, M.; Doran, P.; Stemler, J.; Koehler, P.; Cox, R.J.; O’Shea, D.; Olesen, O.F.; Landay, A.; Hogan, A.E.; Lelievre, J.D.; Gautier, V.; Cornely, O.A.; Mallon, P.W.G.; Leon, A.G.; Feeney, E.; de Barra, E.; Mallon, P. (2023) 'Distinct receptor binding domain IgG thresholds predict protective host immunity across SARS-CoV-2 variants and time'. Nature Communications, 14 . [Link] [DOI] | |
2023 | Gallagher, C.; Mahon, J.M.; O'Neill, C.; Cassidy, F.C.; Dunbar, H.; De Barra, C.; Cadden, C.; Pisarska, M.M.; Wood, N.A.W.; Masterson, J.C.; McNamee, E.N.; Schrumpf, E.; English, K.; O'Shea, D.; Tobin, A.M.; Hogan, A.E. (2023) 'Mucosal-Associated Invariant T Cells Are Altered in Patients with Hidradenitis Suppurativa and Contribute to the Inflammatory Milieu'. Journal of Investigative Dermatology, . [Link] [DOI] | |
2023 | Kedia-Mehta, N.; Pisarska, M.M.; Rollings, C.; O'Neill, C.; De Barra, C.; Foley, C.; Wood, N.A.W.; Wrigley-Kelly, N.; Veerapen, N.; Besra, G.; Bergin, R.; Jones, N.; O'Shea, D.; Sinclair, L.V.; Hogan, A.E. (2023) 'The proliferation of human mucosal-associated invariant T cells requires a MYC-SLC7A5-glycolysis metabolic axis'. Science signaling, 16 . [Link] [DOI] | |
2023 | Cassidy, F.C.; Kedia-Mehta, N.; Bergin, R.; Woodcock, A.; Berisha, A.; Bradley, B.; Booth, E.; Jenkins, B.J.; Ryan, O.K.; Jones, N.; Sinclair, L.V.; O'Shea, D.; Hogan, A.E. (2023) 'Glycogen-fuelled metabolism supports rapid mucosal-associated invariant T cell responses'. Proceedings of the National Academy of Sciences of the United States of America, 120 . [Link] [DOI] | |
2022 | Wrigley Kelly NE; Kenny G; Cassidy FC; Garcia-Leon AA; De Barra C; Mallon PWG; Hogan AE; O'Shea D; (2022) 'Individuals with obesity who survive SARS-CoV-2 infection have preserved antigen specific T cell frequencies'. Obesity, . [DOI] [Full-Text] | |
2022 | Dyck L; Prendeville H; Raverdeau M; Wilk MM; Loftus RM; Douglas A; McCormack J; Moran B; Wilkinson M; Mills EL; Doughty M; Fabre A; Heneghan H; LeRoux C; Hogan A; Chouchani ET; O'Shea D; Brennan D; Lynch L; (2022) 'Suppressive effects of the obese tumor microenvironment on CD8 T cell infiltration and effector function'. Journal of Experimental Medicine, 219 (3). [DOI] [Full-Text] | |
2022 | Cooper A.J.R.; Clegg J.; Cassidy F.C.; Hogan A.E.; McLoughlin R.M. (2022) 'Human MAIT Cells Respond to Staphylococcus aureus with Enhanced Anti-Bacterial Activity'. Microorganisms, 10 (1). [DOI] | |
2022 | Bergin, R; Kinlen, D; Kedia-Mehta, N; Hayes, E; Cassidy, FC; Cody, D; O' Shea, D; Hogan, AE (2022) 'Mucosal-associated invariant T cells are associated with insulin resistance in childhood obesity, and disrupt insulin signalling via IL-17'. Diabetologia, . [DOI] | |
2022 | Schmidt V; Hogan AE; Fallon PG; Schwartz C; (2022) 'Obesity-Mediated Immune Modulation: One Step Forward, (Th)2 Steps Back'. Frontiers in Immunology, 13 . [DOI] | |
2022 | Schwartz C; Schmidt V; Deinzer A; Hawerkamp HC; Hams E; Bayerlein J; Röger O; Bailer M; Krautz C; El Gendy A; Elshafei M; Heneghan HM; Hogan AE; O'Shea D; Fallon PG; (2022) 'Innate PD-L1 limits T cell-mediated adipose tissue inflammation and ameliorates diet-induced obesity'. Science Translational Medicine, 14 (635). [DOI] [Full-Text] | |
2021 | Moynagh P.N.; Hogan A.E. (2021) 'The IRX(3)some factor in macrophages'. Nature Immunology, . [DOI] [Full-Text] | |
2021 | O'Neill C; Cassidy FC; O'Shea D; Hogan AE; (2021) 'Mucosal Associated Invariant T Cells in Cancer-Friend or Foe?'. Cancers, 13 (7). [DOI] [Full-Text] | |
2021 | McCarthy C; O'Donnell CP; Kelly NEW; O'Shea D; Hogan AE; (2021) 'COVID-19 severity and obesity: are MAIT cells a factor?'. The Lancet Respiratory Medicine, . [DOI] [Full-Text] | |
2021 | Kedia-Mehta N.; Tobin L.; Zaiatz-Bittencourt V.; Pisarska M.M.; De Barra C.; Choi C.; Elamin E.; O'Shea D.; Gardiner C.M.; Finlay D.K.; Hogan A.E. (2021) 'Cytokine-induced natural killer cell training is dependent on cellular metabolism and is defective in obesity'. Blood Advances, 5 (21):4447-4455. [DOI] [Full-Text] | |
2020 | Hams E.; Roberts J.; Bermingham R.; Hogan A.E.; O'Shea D.; O'Neill L.; Fallon P.G. (2020) 'Role for Retinoic Acid-Related Orphan Receptor Alpha (RORα) Expressing Macrophages in Diet-Induced Obesity'. Frontiers in Immunology, 11 . [DOI] [Full-Text] | |
2020 | Pisarska MM; Dunne MR; O'Shea D; Hogan AE; (2020) 'Interleukin-17 producing mucosal associated invariant T cells - emerging players in chronic inflammatory diseases?'. European Journal of Immunology, 50 (8). [DOI] [Full-Text] | |
2020 | Naughton, M; Moffat, J; Eleftheriadis, G; Gallardo, ND; Young, A; Falconer, J; Hawkins, K; Pearson, B; Perbal, B; Hogan, A; Moynagh, P; Loveless, S; Robertson, NP; Gran, B; Kee, R; Hughes, S; McDonnell, G; Howell, O; Fitzgerald, DC (2020) 'CCN3 is dynamically regulated by treatment and disease state in multiple sclerosis'. Journal of Neuroinflammation, 17 . [DOI] [Full-Text] | |
2020 | O' Brien, A; Kedia-Mehta, N; Tobin, L; Veerapen, N; Besra, GS; O' Shea, D; Hogan, AE (2020) 'Targeting mitochondrial dysfunction in MAIT cells limits IL-17 production in obesity'. Cellular and Molecular Immunology, . [DOI] [Full-Text] | |
2019 | O'Shea D; Hogan AE; (2019) 'Dysregulation of Natural Killer Cells in Obesity'. Cancers, 11 (4). [DOI] [Full-Text] | |
2019 | Melo AM; O'Brien AM; Phelan JJ; Kennedy SA; Wood NAW; Veerapen N; Besra GS; Clarke NE; Foley EK; Ravi A; MacCarthy F; O'Toole D; Ravi N; Reynolds JV; Conroy MJ; Hogan AE; O'Sullivan J; Dunne MR; (2019) 'Mucosal-Associated Invariant T Cells Display Diminished Effector Capacity in Oesophageal Adenocarcinoma'. Frontiers in Immunology, 10 . [DOI] [Full-Text] | |
2019 | Brennan K; O'Leary BD; Mc Laughlin D; Kinlen D; Molloy EJ; Cody D; Paran S; McAuliffe FM; Hogan AE; Doyle SL; (2019) 'Nucleic acid cytokine responses in obese children and infants of obese mothers'. Cytokine, 119 . [DOI] [Full-Text] | |
2019 | Giannoudaki E; Hernandez-Santana YE; Mulfaul K; Doyle SL; Hams E; Fallon PG; Mat A; O'Shea D; Kopf M; Hogan AE; Walsh PT; (2019) 'Interleukin-36 cytokines alter the intestinal microbiome and can protect against obesity and metabolic dysfunction'. Nature Communications, 10 (1). [DOI] [Full-Text] | |
2019 | O'Brien A; Loftus RM; Pisarska MM; Tobin LM; Bergin R; Wood NAW; Foley C; Mat A; Tinley FC; Bannan C; Sommerville G; Veerapen N; Besra GS; Sinclair LV; Moynagh PN; Lynch L; Finlay DK; O'Shea D; Hogan AE; (2019) 'Obesity Reduces mTORC1 Activity in Mucosal-Associated Invariant T Cells, Driving Defective Metabolic and Functional Responses'. Journal of Immunology, 202 (12). [DOI] [Full-Text] | |
2018 | Michelet X; Dyck L; Hogan A; Loftus RM; Duquette D; Wei K; Beyaz S; Tavakkoli A; Foley C; Donnelly R; O'Farrelly C; Raverdeau M; Vernon A; Pettee W; O'Shea D; Nikolajczyk BS; Mills KHG; Brenner MB; Finlay D; Lynch L; (2018) 'Metabolic reprogramming of natural killer cells in obesity limits antitumor responses'. Nature Immunology, 19 (12). [DOI] [Full-Text] | |
2011 | O'Connell, J; Lynch, L; Hogan, A; Cawood, TJ; O'Shea, D (2011) 'Preadipocyte Factor-1 Is Associated with Metabolic Profile in Severe Obesity'. Journal of Clinical Endocrinology and Metabolism, 96 :680-684. [DOI] |
Reviews
Year | Publication | |
---|---|---|
2022 | Breen C.; O'Connell J.; Geoghegan J.; O'Shea D.; Birney S.; Tully L.; Gaynor K.; O'Kelly M.; O'Malley G.; O'Donovan C.; Lyons O.; Flynn M.; Allen S.; Arthurs N.; Browne S.; Byrne M.; Callaghan S.; Collins C.; Courtney A.; Crotty M.; Donohue C.; Donovan C.; Dunlevy C.; Duggan D.; Fearon N.; Finucane F.; Fitzgerald I.; Foy S.; Garvey J.; Gibson I.; Glynn L.; Gregg E.; Griffin A.; Harrington J.M.; Heary C.; Heneghan H.; Hogan A.; Hynes M.; Kearney C.; Kelly D.; Neff K.; Le Roux C.W.; Manning S.; McAuliffe F.; Moore S.; Moran N.; Murphy M.; Murrin C.; O'Brien S.M.; O'Donnell C.; O'Dwyer S.; O'Grada C.; O'Malley E.; O'Reilly O.; O'Reilly S.; Porter O.; Roche H.M.; Rhynehart A.; Ryan L.; Seery S.; Soare C.; Shaamile F.; Walsh A.; Woods C.; Yoder R. (2022) Obesity in Adults: A 2022 Adapted Clinical Practice Guideline for Ireland. [Reviews] [DOI] | |
2020 | Pisarska M.M.; Dunne M.R.; O'Shea D.; Hogan A.E. (2020) Interleukin-17 producing mucosal associated invariant T cells - emerging players in chronic inflammatory diseases?. [Reviews] [DOI] [Full-Text] |
Publication Letters
Year | Publication | |
---|---|---|
2017 | Malara A; Hughes R; Jennings L; Sweeney CM; Lynch M; Awdeh F; Timoney I; Tobin AM; Lynam-Loane K; Tobin L; Hogan A; O'Shea D; Kirby B; (2017) Adipokines are dysregulated in patients with hidradenitis suppurativa. [Publication Letters] [DOI] |