Dr Shirley O'Dea

    Biology, Human Health Institute

    Associate Professor
    Biotechnology Programme Coordinator

    Callan
    1st Floor
    F7
    (01) 7086480

    Biography

    Dr. O'Dea (B.Sc., University College Dublin; Ph.D., Dublin City University, 1995) received a Marie Curie Fellowship and a Salvesen Fellowship to work at Edinburgh University (1997-2001) before coming to Maynooth University as a Science Foundation Ireland-funded investigator. She was appointed Lecturer in the Biology Department, NUIM in 2005 and Associate Professor in 2012. Dr. O'Dea is co-founder of the spin-out company Avectas (www.avectas.com).

    Peer Reviewed Journal

    Year Publication
    2021 Kavanagh, H; Dunne, S; Martin, DS; McFadden, E; Gallagher, L; Schwaber, J; Leonard, S; O'Dea, S (2021) 'A novel non-viral delivery method that enables efficient engineering of primary human T cells for ex vivo cell therapy applications'. Cytotherapy, 23 :852-860. [DOI] [Full-Text]
    2018 Riddell, P; Gilbert, JL; Molloy, EL; Finnegan, S; Egan, JJ; O' Dea, S (2018) 'Delivery of nucleic acids to ex vivo porcine airways using electrospray'. Experimental Lung Research, 44 :405-416. [DOI] [Full-Text]
    2018 McCrea Z.; Arnanthigo Y.; Cryan S.; O’Dea S. (2018) 'A Novel Methodology for Bio-electrospraying Mesenchymal Stem Cells that Maintains Differentiation, Immunomodulatory and Pro-reparative Functions'. Journal of Medical and Biological Engineering, 38 (3):497-513. [DOI] [Full-Text]
    2017 O'Dea S; Annibaldi V; Gallagher L; Mulholland J; Molloy EL; Breen CJ; Gilbert JL; Martin DS; Maguire M; Curry FR; (2017) 'Vector-free intracellular delivery by reversible permeabilization'. PLoS ONE, 12 (3). [DOI] [Full-Text]
    2016 Lynn TM; Molloy EL; Masterson JC; Glynn SF; Costello RW; Avdalovic MV; Schelegle ES; Miller LA; Hyde DM; O'Dea S; (2016) 'SMAD Signaling in the Airways of Healthy Rhesus Macaques versus Rhesus Macaques with Asthma Highlights a Relationship Between Inflammation and Bone Morphogenetic Proteins'. American Journal of Respiratory Cell and Molecular Biology, 54 (4). [DOI] [Full-Text]
    2016 O'Leary C.; Cavanagh B.; Unger R.; Kirkpatrick C.; O'Dea S.; O'Brien F.; Cryan S. (2016) 'The development of a tissue-engineered tracheobronchial epithelial model using a bilayered collagen-hyaluronate scaffold'. Biomaterials, 85 :111-127. [DOI] [Full-Text]
    2016 Kerr L.; Lynn T.; Cullen I.; Daly P.; Shah N.; O'Dea S.; Malkin A.; Hennelly B. (2016) 'Methodologies for bladder cancer detection with Raman based urine cytology'. Analytical Methods, 8 (25):4991-5000. [DOI]
    2015 O'Leary C; Gilbert JL; O'Dea S; O'Brien FJ; Cryan SA; (2015) 'Respiratory Tissue Engineering: Current Status and Opportunities for the Future'. Tissue Engineering - Part B: Reviews, 21 (4). [DOI]
    2014 Judge EP; Hughes JM; Egan JJ; Maguire M; Molloy EL; O'Dea S; (2014) 'Anatomy and bronchoscopy of the porcine lung. A model for translational respiratory medicine'. American Journal of Respiratory Cell and Molecular Biology, 51 (3). [DOI] [Full-Text]
    2013 Noone C.; Kihm A.; English K.; O'Dea S.; Mahon B. (2013) 'IFN-gamma stimulated human umbilical-tissue-derived cells potently suppress NK activation and resist NK-mediated cytotoxicity in vitro'. Stem Cells and Development, 22 (22):3003-3014. [DOI] [Full-Text]
    2013 McCormack N; O'Dea S; (2013) 'Regulation of epithelial to mesenchymal transition by bone morphogenetic proteins'. Cellular Signalling, 25 (12). [DOI] [Full-Text]
    2013 McCormack, N; Molloy, EL; O'Dea, S (2013) 'Bone morphogenetic proteins enhance an epithelial-mesenchymal transition in normal airway epithelial cells during restitution of a disrupted epithelium'. Respiratory Research, 14 . [DOI] [Full-Text]
    2012 Keenan, J; Joyce, H; Aherne, S; O'Dea, S; Doolan, P; Lynch, V; Clynes, M (2012) 'Olfactomedin III expression contributes to anoikis-resistance in clonal variants of a human lung squamous carcinoma cell line'. Experimental Cell Research, 318 :593-602. [DOI] [Full-Text]
    2011 Masterson, JC; Molloy, EL; Gilbert, JL; McCormack, N; Adams, A; O'Dea, S (2011) 'Bone morphogenetic protein signalling in airway epithelial cells during regeneration'. Cellular Signalling, 23 :398-406. [DOI] [Full-Text]
    2009 Field-Corbett, C; English, K; O'Dea, S (2009) 'Regulation of Surfactant Protein B Gene Expression in Bone Marrow-Derived Cells'. Stem Cells, 27 :662-669. [DOI] [Full-Text]
    2008 Molloy, EL; Adams, A; Moore, JB; Masterson, JC; Madrigal-Estebas, L; Mahon, BP; O'Dea, S (2008) 'BMP4 induces an epithelial-mesenchymal transition-like response in adult airway epithelial cells'. Growth Factors, 26 :12-22. [DOI] [Full-Text]
    2008 Gilbert, JL; Purcell, J; Strappe, P; McCabe, M; O'Brien, T; O'Dea, S (2008) 'Comparative evaluation of viral, nonviral and physical methods of gene delivery to normal and transformed lung epithelial cells'. Anti-Cancer Drugs, 19 :783-788. [DOI] [Full-Text]
    2008 Codoner, FM; O'Dea, S; Fares, MA (2008) 'Reducing the false positive rate in the non-parametric analysis of molecular coevolution'. BMC Evolutionary Biology, 8 . [DOI] [Full-Text]
    2008 McGauran, AMT; Barry, D; Moore, JB; Madsen, D; O'Dea, S; Mahon, BP; Commins, S (2008) 'A possible role for protein synthesis, extracellular signal-regulated kinase, and brain-derived neurotrophic factor in long-term spatial memory retention in the water maze'. Behavioral Neuroscience, 122 :805-815. [DOI] [Full-Text]
    2007 Masterson J; O'Dea S; (2007) 'Posttranslational truncation of E-cadherin and significance for tumour progression'. Cells Tissues Organs, 185 (1-3). [DOI] [Full-Text]
    2007 Masterson, J.C. and ODea, S. (2007) '5-Bromo-2-deoxyuridine activates DNA damage signaling responses and induces a senescence-like phenotype in p16-null lung cancer cells'. Anti-Cancer Drugs, 18 :1053-1068. [Full-Text]
    2007 Field-Corbett, C; O'Dea, S (2007) 'Soluble signals from mechanically disrupted lung tissue induce lung-related gene expression in bone marrow-derived cells in vitro'. Stem Cells and Development, 16 :231-241. [DOI] [Full-Text]
    2004 Blundell, R; Harrison, DJ; O'Dea, S (2004) 'P21(Waf1/Cip1) regulates proliferation and apoptosis in airway epithelial cells and alternative forms have altered binding activities'. Experimental Lung Research, 30 :447-464. [DOI] [Full-Text]
    2002 O'Dea S; Harrison DJ; (2002) 'CFTR gene transfer to lung epithelium--on the trail of a target cell'. Current Gene Therapy, 2 (2). [DOI]
    2002 Armit, C. J., O'Dea, S., Clarke, A.R. and Harrison, D. J. (2002) 'Absence of p53 in lung epithelial cells favours multinucleation and loss of cell cycle arrest'. BMC Cell Biology, 3 . [Full-Text]
    2000 McBride, S., Tatrai, E., Blundell, R., Kovacikova, Z., Cardozo, L., Adamis, Z., Smith, T. and Harrison, D. (2000) 'Characterisation of lectin binding patterns of mouse bronchiolar and rat alveolar epithelial cells in culture'. Histochemical Journal, 32 :33-40. [Full-Text]
    2000 McBride, S., Rannie, D. and Harrison, D. (2000) 'Gene transfer to adult human lung tissue ex vivo'. Gene Therapy, 7 :675-678. [Full-Text]
    1999 McBride, S., Walsh, D., Meleady, P., Daly, N. and Clynes, M. (1999) 'Bromodeoxyuridine induces keratin protein synthesis at a posttranscriptional level in human lung tumour cell lines'. DIFFERENTIATION, 64 :185-193. [Full-Text]
    1998 McBride, S., .Meleady, P., .Baird, A., .Dinsdale, D. and Clynes, M. (1998) 'Human lung carcinoma cell line DLKP contains 3 distinct subpopulations with different growth and attachment properties'. Tumor Biology, 19 :88-103. [Full-Text]
    1996 Daly, C., Coyle, S., McBride, S., O'Driscoll, L., Daly, N., Scanlon, K. and Clynes, M. (1996) 'Mdr-1 ribozyme-mediated reversal of the multi-drug resistant phenotype in human lung cell lines'. Cytotechnology, 19 :199-205. [Full-Text]
    1995 Clynes, M., Heenan, M., McBride, S., Cleary, I., Doherty, G., O'Driscoll, L. and Moran, E. (1995) 'Multiple drug resistance in variants of a human lung line exposed to adriamycin and VP-16'. Journal of Experimental and Clinical Cancer Research, 14 :15-16. [Full-Text]

    Book Chapter

    Year Publication
    1998 O'Sullivan, F., Meleady, P., McBride, S. and Clynes, M. (1998) 'Primary culture' In: Animal Cell Culture Technique; Springer Lab Manual. : Springer-Verlag.
    1998 Meleady, P., O'Sullivan, F., McBride, S. and Clynes, M. (1998) 'Isolation, cultivation and differentiation of lung type II epithelial cells' In: Animal Cell Culture Techniques; Springer Lab Manual. Berlin, Germany : Springer-Verlag.
    1998 McBride, S. and Clynes, M. (1998) 'Investigations into cell differentiation using cells in culture' In: Animal Cell Culture Technique; Springer Lab Manual. : Springer-Verlag.
    1998 McBride, S., Heenan, M. and Clynes M. (1998) 'Cloning animal cells' In: Animal Cell Culture Technique; Springer Lab Manual. : Springer-Verlag.
    Certain data included herein are derived from the © Web of Science (2023) of Clarivate. All rights reserved.

    Professional Associations

    Description Function From / To
    International Society for Cell and Gene Therapy Member -

    Honors and Awards

    Date Title Awarding Body
    01/01/2021 Biotech Company of the Year - Avectas Pharma Industry Awards
    01/01/2019 BioScience Laboratory of the Year - Avectas Irish Laboratory Awards
    01/01/2019 Innovation of the Year - Spraybase Melt Electrospinning - Avectas Irish Laboratory Awards
    01/01/2014 Annual Commercialisation Award Maynooth University
    01/01/1999 Salveson Trust Fellowship Salveson Trust, UK
    01/01/1997 Marie Curie Fellowship European Union