Prof Bernard Mahon

    Biology, Hamilton Institute, Human Health Institute

    Professor

    Biosciences & Electronic Engineering Facility
    1st
    B2.15
    (01) 708 3835

    Biography

    My scientific work is based on hypothesis-driven, fundamental studies of murine and human immunology. Two major topics are addressed:
    1. How do adult mesenchymal stem cells modulate immunity (a question with implications for stem cell therapy, transplantation and tolerance).  This work finds application is the design of new cell based therapies;
    2. The immunology of early life, particularly at the mucosal surface of the airways. This has led me to examine early life infections with the pathogens B. pertussis, poliovirus and B19V, work which has implications for vaccine design, immunisation protocols and diagnostics.
    When appropriate, my work has been commercialised or translated to clinical settings. Key recent advances: a) Overcoming the technical problems of adult stem cell therapy; b) a clinical trial of a new whooping cough vaccine with EU partners. I previously served as Faculty dean and VP Research.     

    Research Interests

    Key Words: Immunology, adult stem cells, cell therapy, vaccines, GvHD, infants, adverse events.My scientific work is based on hypothesis-driven, fundamental studies of murine and human immunology. Two major topics are addressed:
    1. How do adult mesenchymal stem cells modulate immunity? (a question with implications for stem cell therapy, transplantation and tolerance).  This work finds application is the design of new cell based therapies; 
    2. The immunology of early life, particularly at the mucosal surface of the airways. This has led me to examine early life infections with the pathogens B. pertussis, poliovirus and B19V, work which has implications for vaccine design, immunisation protocols and diagnostics.
    When appropriate, my work has been commercialised or translated to clinical settings. Key recent advances: a) Overcoming the technical problems of adult stem cell therapy; b) a clinical trial of a new whooping cough vaccine with EU partners.

    Peer Reviewed Journals

      Year Publication
    2017 'The influence of macrophages on mesenchymal stromal cell therapy: passive or aggressive agents?'
    Carty, F;Mahon, BP;English, K (2017) 'The influence of macrophages on mesenchymal stromal cell therapy: passive or aggressive agents?'. Clinical and Experimental Immunology, 188 :1-11 [DOI] [full-text] [Details]
    2016 'Human mesenchymal stromal cells exert HGF dependent cytoprotective effects in a human relevant pre-clinical model of COPD'
    Kennelly, H;Mahon, BP;English, K (2016) 'Human mesenchymal stromal cells exert HGF dependent cytoprotective effects in a human relevant pre-clinical model of COPD'. Scientific Reports, 6 [DOI] [full-text] [Details]
    2011 'IL-17A Induces CCL28, Supporting the Chemotaxis of IgE-Secreting B Cells'
    Scanlon, KM;Hawksworth, RJ;Lane, SJ;Mahon, BP (2011) 'IL-17A Induces CCL28, Supporting the Chemotaxis of IgE-Secreting B Cells'. International Archives of Allergy and Immunology, 156 :51-61 [DOI] [Details]
    2008 'The absence of specific virulence factors in a live attenuated Bordetella pertussis candidate vaccine strain ablates atypical pathologies in IFN-gamma R knockout mice'
    Skerry, CM;Locht, C;Mahon, B (2008) 'The absence of specific virulence factors in a live attenuated Bordetella pertussis candidate vaccine strain ablates atypical pathologies in IFN-gamma R knockout mice'. IMMUNOLOGY, 125 :141-142 [Details]
    1998 'Approaches to new vaccines'
    Mahon B.;Moore A.;Johnson P.;Mills K. (1998) 'Approaches to new vaccines'. Critical Reviews in Biotechnology, 18 (4):257-282 [DOI] [Details]
    1998 'Pertussis infection and vaccination induces Th1 cells [2]'
    Brady M.;Mahon B.;Mills K. (1998) 'Pertussis infection and vaccination induces Th1 cells [2]'. Immunology Today, 19 (11) [DOI] [full-text] [Details]
    1998 'Irish thoracic society - Proceeds of annual scientific meeting held Friday & Saturday 8th & 9th November, 1996'
    Coakley R.;O'Neill S.;Coakley R.;Glynn P.;O'Neill S.;Finlay G.;Russell K.;McMahon K.;D'Arcy E.;Masterson J.;Fitzgerald M.;O'Connor C.;O'Driscoll L.;Finlay G.;Fitzgerald M.;O'Connor C.;McGarvey L.;Forsythe P.;Heaney L.;MacMahon J.;Ennis M.;Leonard C.;Tormey V.;Burke C.;Poulter L.;Keatings V.;FitzGerald M.;Barnes P.;Harty H.;Corfield D.;Adams L.;Schwartzstein R.;Kiely J.;Buckley A.;Shiels P.;Deegan P.;Maurer B.;McNicholas W.;Dunlop K.;Martin B.;Riley M.;Shields M.;Glynn P.;Kilgallen I.;Coakley R.;O'Neill S.;McElvaney N.;Cervantes-Laurean D.;Wehr N.;Gabriele K.;Robinson W.;Moss J.;Levine R.;Urbach V.;Walsh D.;Harvey B.;McElroy M.;Pittet J.;Allen L.;Wiener-Kroonish J.;Dobbs L.;O'Donnell D.;McMahon K.;O'Connor C.;Fitzgerald M.;McGuirk P.;Mahon B.;Griffin F.;Mills K.;Murphy R.;Brijker F.;Mulloy E.;Cohen Tervaert J.;Walshe J.;O'Neill S.;McGarvey L.;Heaney L.;Lowry R.;Shepherd D.;MacMahon J. (1998) 'Irish thoracic society - Proceeds of annual scientific meeting held Friday & Saturday 8th & 9th November, 1996'. Irish Journal of Medical Science, 167 (9 Supplement):1-13 [DOI] [full-text] [Details]
    1998 'A respiratory challenge model for infection with Bordetella pertussis: application in the assessment of pertussis vaccine potency and in defining the mechanism of protective immunity'
    Mills K.;Brady M.;Ryan E.;Mahon B. (1998) 'A respiratory challenge model for infection with Bordetella pertussis: application in the assessment of pertussis vaccine potency and in defining the mechanism of protective immunity'. Developments in Biological Standardization, 95 :31-41 [Details]
    1996 'CD4(+) MHC class II-restricted Th1 clones specific for poliovirus induce apoptosis in B cells: Implications for their cytolytic and helper functions'
    Conway, M;Mahon, B;Mills, KHG (1996) 'CD4(+) MHC class II-restricted Th1 clones specific for poliovirus induce apoptosis in B cells: Implications for their cytolytic and helper functions'. Journal of Immunology, 89 :174-174 [Details]
    2016 'Linocin and OmpW Are Involved in Attachment of the Cystic Fibrosis-Associated Pathogen Burkholderia cepacia Complex to Lung Epithelial Cells and Protect Mice against Infection'
    McClean S;Healy ME;Collins C;Carberry S;O'Shaughnessy L;Dennehy R;Adams Á;Kennelly H;Corbett JM;Carty F;Cahill LA;Callaghan M;English K;Mahon BP;Doyle S;Shinoy M; (2016) 'Linocin and OmpW Are Involved in Attachment of the Cystic Fibrosis-Associated Pathogen Burkholderia cepacia Complex to Lung Epithelial Cells and Protect Mice against Infection'. Infection and Immunity, 84 (5) [DOI] [full-text] [Details]
    2016 'Hepatocyte Growth Factor Is Required for Mesenchymal Stromal Cell Protection Against Bleomycin-Induced Pulmonary Fibrosis'
    Cahill EF;Kennelly H;Carty F;Mahon BP;English K; (2016) 'Hepatocyte Growth Factor Is Required for Mesenchymal Stromal Cell Protection Against Bleomycin-Induced Pulmonary Fibrosis'. Stem cells translational medicine, 5 (10) [DOI] [full-text] [Details]
    2005 'Mesenchymal stem cells avoid allogeneic rejection'
    Ryan J.;Barry F.;Murphy J.;Mahon B. (2005) 'Mesenchymal stem cells avoid allogeneic rejection'. JOURNAL OF INFLAMMATION, 2 [DOI] [full-text] [Details]
    2015 'Jagged-1 is required for the expansion of CD4+ CD25+ FoxP3+ regulatory T cells and tolerogenic dendritic cells by murine mesenchymal stromal cells'
    Cahill E.;Tobin L.;Carty F.;Mahon B.;English K. (2015) 'Jagged-1 is required for the expansion of CD4+ CD25+ FoxP3+ regulatory T cells and tolerogenic dendritic cells by murine mesenchymal stromal cells'. Stem Cell Research and Therapy, 6 (1) [DOI] [full-text] [Details]
    2013 'IFN-gamma stimulated human umbilical-tissue-derived cells potently suppress NK activation and resist NK-mediated cytotoxicity in vitro'
    Noone C.;Kihm A.;English K.;O'Dea S.;Mahon B. (2013) 'IFN-gamma stimulated human umbilical-tissue-derived cells potently suppress NK activation and resist NK-mediated cytotoxicity in vitro'. Stem Cells and Development, 22 (22):3003-3014 [DOI] [full-text] [Details]
    2013 'Mesenchymal Stem Cells in Solid Organ Transplantation (MiSOT) Fourth Meeting: Lessons Learned from First Clinical Trials'
    Franquesa, M;Hoogduijn, MJ;Reinders, ME;Eggenhofer, E;Engela, AU;Mensah, FK;Torras, J;Pileggi, A;van Kooten, C;Mahon, B;Detry, O;Popp, FC;Benseler, V;Casiraghi, F;Johnson, C;Ancans, J;Fillenberg, B;delaRosa, O;Aran, JM;Roemeling-vanRhijn, M;Pinxteren, J;Perico, N;Gotti, E;Christ, B;Reading, J;Introna, M;Deans, R;Shagidulin, M;Farre, R;Rambaldi, A;Sanchez-Fueyo, A;Obermajer, N;Pulin, A;Dor, FJMF;Portero-Sanchez, I;Baan, CC;Rabelink, TJ;Remuzzi, G;Betjes, MGH;Dahlke, MH;Grinyo, JM (2013) 'Mesenchymal Stem Cells in Solid Organ Transplantation (MiSOT) Fourth Meeting: Lessons Learned from First Clinical Trials'. Transplantation, 96 :234-238 [DOI] [full-text] [Details]
    2011 'Allogeneic mesenchymal stem cells prevent allergic airway inflammation by inducing murine regulatory T cells'
    Kavanagh H.;Mahon B. (2011) 'Allogeneic mesenchymal stem cells prevent allergic airway inflammation by inducing murine regulatory T cells'. Allergy: European Journal of Allergy and Clinical Immunology, 66 (4):523-531 [DOI] [full-text] [Details]
    2010 'Adult Mesenchymal Stem Cells - Intelligent therapies for immune reprogramming'
    Kavanagh H., and B.P. Mahon. (2010) 'Adult Mesenchymal Stem Cells - Intelligent therapies for immune reprogramming'. INTERNATIONAL DRUG DISCOVERY, 5 :46-51 [Details]
    2010 'Immunological Aspects of Allogeneic Mesenchymal Stem Cell Therapies'
    Griffin MD, Ritter T, and B.P. Mahon (2010) 'Immunological Aspects of Allogeneic Mesenchymal Stem Cell Therapies'. HUMAN GENE THERAPY, 21 :1641-1655 [DOI] [full-text] [Details]
    2010 'The attenuated Bordetella pertussis vaccine strain BPZE1 prevents exacerbated allergic pathology in a murine model'
    Kavanagh H, English K, Locht C, and B.P. Mahon. (2010) 'The attenuated Bordetella pertussis vaccine strain BPZE1 prevents exacerbated allergic pathology in a murine model'. CLINICAL AND EXPERIMENTAL ALLERGY, 40 :933-941 [full-text] [Details]
    2010 'Zinc and Silver Glass Polyalkenoate Cement Solutions: An Evaluation of their Antibacterial Nature Through in vitro and in vivo Testing'
    Coughlan, A., K. Scanlon, B.P. Mahon & M.R. Towler. (2010) 'Zinc and Silver Glass Polyalkenoate Cement Solutions: An Evaluation of their Antibacterial Nature Through in vitro and in vivo Testing'. BIO-MEDICAL MATERIALS AND ENGINEERING, 20 :99-106 [full-text] [Details]
    2009 'Cell Contact, Prostaglandin E2 and Transforming growth factor beta 1 play non redundant roles in Human Mesenchymal Stem Cell Induction of CD4+CD25HighFoxp3+ Regulatory T cells'
    English, K., J.R. Ryan, L. Tobin, M.J. Murphy, F.P. Barry and B.P. Mahon. (2009) 'Cell Contact, Prostaglandin E2 and Transforming growth factor beta 1 play non redundant roles in Human Mesenchymal Stem Cell Induction of CD4+CD25HighFoxp3+ Regulatory T cells'. CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 156 :149-160 [DOI] [full-text] [Details]
    2008 'Murine mesenchymal stem cells suppress dendritic cell migration, maturation and function'
    K.  English, F. P. Barry and B.  P.  Mahon.  (2008) 'Murine mesenchymal stem cells suppress dendritic cell migration, maturation and function'. IMMUNOLOGY LETTERS, 115 :50-58 [full-text] [Details]
    2008 'A possible role for protein synthesis, ERK and BDNF in long-term spatial memory retention in the water maze'
    McGauran, A.T., J.B. Moore, D. Madsen, D. Barry, S. O’Dea, B.P. Mahon and S. Commins (2008) 'A possible role for protein synthesis, ERK and BDNF in long-term spatial memory retention in the water maze'. BEHAVIORAL NEUROSCIENCE, 122 :805-815 [full-text] [Details]
    2007 'IFN-g and TNF-a differentially regulate immunomodulation by murine mesenchymal stem cells'
    English K.;Barry F.;Field-Corbett C.;Mahon B. (2007) 'IFN-g and TNF-a differentially regulate immunomodulation by murine mesenchymal stem cells'. Immunology Letters, 110 (2):91-100 [DOI] [full-text] [Details]
    2006 'Interleukin-10 (IL-10) but not Lipopolysaccharide (LPS) produces increased motor activity and abnormal exploratory patterns while impairing spatial learning in Balb/c mice'
    Harvey, D;Smith, R;English, K;Mahon, B;Commins, S (2006) 'Interleukin-10 (IL-10) but not Lipopolysaccharide (LPS) produces increased motor activity and abnormal exploratory patterns while impairing spatial learning in Balb/c mice'. Physiology and Behavior, 87 :842-847 [DOI] [full-text] [Details]
    2005 'Whole cell pertussis vaccine protects against Bordetella pertussis exacerbation of allergic asthma:  Pw immunization reduces IL-13 and IL-10'
    D.P. Ennis, J.P. Cassidy, and B.P. Mahon.  (2005) 'Whole cell pertussis vaccine protects against Bordetella pertussis exacerbation of allergic asthma:  Pw immunization reduces IL-13 and IL-10'. Immunology Letters, 97 :91-100 [full-text] [Details]
    2005 'IL-1beta and TNF-alpha induce increased expression of CCL28 by airway epithelial cells via an NFκB-dependent pathway'
    O'Gorman M.;Jatoi N.;Lane S.;Mahon B. (2005) 'IL-1beta and TNF-alpha induce increased expression of CCL28 by airway epithelial cells via an NFκB-dependent pathway'. Cellular Immunology, 238 (2):87-96 [DOI] [full-text] [Details]
    2005 'Mesenchymal Stem Cell Transplantation for Tissue Repair'
    F. P. Barry, J. M. Murphy, T. O’Brien and B. P. Mahon (2005) 'Mesenchymal Stem Cell Transplantation for Tissue Repair'. SEMINARS IN PLASTIC SURGERY, 19 :229-240 [full-text] [Details]
    2005 'Immunogenicity of adult mesenchymal stem cells: lessons from the fetal allograft. '
    F.P. Barry, J.M. Murphy, K. English and B.P. Mahon. (2005) 'Immunogenicity of adult mesenchymal stem cells: lessons from the fetal allograft. '. Stem Cells and Development, 14 :252-265 [Details]
    2005 'Novel mechanism of immunosuppression by influenza virus haemagglutinin:  selective suppression of IL-12p35 transcription'
    C.M. Noone, A.B. Frawely, M.F. Doyle, B.P. Mahon, K.H.G. Mills and. P.A. Johnson.  (2005) 'Novel mechanism of immunosuppression by influenza virus haemagglutinin:  selective suppression of IL-12p35 transcription'. JOURNAL OF GENERAL VIROLOGY, 86 :1885-1890 [full-text] [Details]
    2005 'Acellular pertussis vaccine protects against Bordetella pertussis exacerbation of allergic asthma but in the absence of infection potentiates airway IL-10 and IL-13'
    D. P. Ennis, J. P. Cassidy, and B. P. Mahon. (2005) 'Acellular pertussis vaccine protects against Bordetella pertussis exacerbation of allergic asthma but in the absence of infection potentiates airway IL-10 and IL-13'. Clinical and Diagnostic Laboratory Immunology, 12 :409-417 [full-text] [Details]
    2004 'Efficient delivery of small interfering RNA for inhibition of IL-12p40 expression in vivo'
    Flynn M.;Casey D.;Todryk S.;Mahon B. (2004) 'Efficient delivery of small interfering RNA for inhibition of IL-12p40 expression in vivo'. Journal of Inflammation, 1 [DOI] [full-text] [Details]
    2004 'B cell memory is directed towards conformational epitopes of parvovirus B19 capsid proteins and the VP1-unique region. Journal of Infectious Diseases. 189:1873-1880'
    A. Corcoran, B. P. Mahon and S. Doyle. (2004) 'B cell memory is directed towards conformational epitopes of parvovirus B19 capsid proteins and the VP1-unique region. Journal of Infectious Diseases. 189:1873-1880'. JOURNAL OF INFECTIOUS DISEASES, 183 :1873-1880 [full-text] [Details]
    2004 'Prior Bordetella pertussis infection influences allergen priming and the severity of airway pathology in a murine model of allergic asthma'
    D. P. Ennis, J. P. Cassidy, and B. P. Mahon. (2004) 'Prior Bordetella pertussis infection influences allergen priming and the severity of airway pathology in a murine model of allergic asthma'. CLINICAL AND EXPERIMENTAL ALLERGY, 34 :1488-1497 [full-text] [Details]
    2004 'Efficient delivery of small interfering RNA for inhibition of IL-12p40 expression in vivo. '
    M. Flynn, D. Casey. S. Todryk, and B. P. Mahon (2004) 'Efficient delivery of small interfering RNA for inhibition of IL-12p40 expression in vivo. '. JOURNAL OF INFLAMMATION, 1 :1-12 [full-text] [Details]
    2002 'High-sensitivity PCR detection of parvovirus B19 in plasma'
    Daly P.;Corcoran A.;Mahon B.;Doyle S. (2002) 'High-sensitivity PCR detection of parvovirus B19 in plasma'. Journal of Clinical Microbiology, 40 (6):1958-1962 [DOI] [full-text] [Details]
    2001 'The immunological role of respiratory tract epithelium'
    R. Cunningham and B. P. Mahon (2001) 'The immunological role of respiratory tract epithelium'. Modern Aspects of Immunobiology, 1 :204-208 [Details]
    2001 'The rational design of vaccine adjuvants for mucosal and neonatal immunization'
    Mahon B. (2001) 'The rational design of vaccine adjuvants for mucosal and neonatal immunization'. Current Medicinal Chemistry, 8 (9):1057-1075 [Details]
    2000 'Protection against Bordetella pertussis in mice in the absence of circulating antibody: Implications for long term immunity in children'
    B. P. Mahon, M. T. Brady and K. H. G. Mills. (2000) 'Protection against Bordetella pertussis in mice in the absence of circulating antibody: Implications for long term immunity in children'. JOURNAL OF INFECTIOUS DISEASES, 181 :2087-2091 [full-text] [Details]
    2000 'Impaired interferon-g responses against Parvovirus B19 by recently infected children'
    A. Corcoran, S. Doyle, D. Waldron, A. Nicholson, and B. P. Mahon. (2000) 'Impaired interferon-g responses against Parvovirus B19 by recently infected children'. JOURNAL OF VIROLOGY, 74 :9903-9910 [full-text] [Details]
    2000 'Protection against Bordetella pertussis in mice in the absence of detectable circulating antibody: Implications for long-term immunity in children'
    Mahon B.;Brady M.;Mills K. (2000) 'Protection against Bordetella pertussis in mice in the absence of detectable circulating antibody: Implications for long-term immunity in children'. Journal of Infectious Diseases, 181 (6):2087-2091 [DOI] [full-text] [Details]
    1999 'Pertussis infection and vaccination induce Th1 cells and does not enhance allergy'
    M. Brady, B. P. Mahon, and K. H. G. Mills. (1999) 'Pertussis infection and vaccination induce Th1 cells and does not enhance allergy'. Trends in Immunology, 19 :534-534 [Details]
    1999 'Interferon-g mediated immune effector mechanisms against Bordetella pertussis'
    B. P. Mahon, and K. H. G. Mills. (1999) 'Interferon-g mediated immune effector mechanisms against Bordetella pertussis'. IMMUNOLOGY LETTERS, 68 :213-217 [full-text] [Details]
    1999 'The immunology of Bordetella pertussis infection'
    Mills, KHG;Ryan, M;McGuirk, P;Griffin, F;Murphy, G;Mahon, B (1999) 'The immunology of Bordetella pertussis infection'. Biologicals, 27 :77-77 [full-text] [Details]
    1998 'PT potentiates Th1 and Th2 responses to co-injected antigen: adjuvant action is associated with enhanced regulatory cytokine production and expression of the co-stimulatory molecules B7-1, B7-2 and CD28'
    M. Ryan, L. McCarthy, B. P. Mahon, R. Rappuoli, and K. H. G. Mills. (1998) 'PT potentiates Th1 and Th2 responses to co-injected antigen: adjuvant action is associated with enhanced regulatory cytokine production and expression of the co-stimulatory molecules B7-1, B7-2 and CD28'. International Immunology, 10 :651-662 [full-text] [Details]
    1998 'A respiratory challenge model for infection with Bordetella pertussis: application in the assessment of pertussis vaccine potency and in the definition of the mechanism of protective immunity'
    K. H. G. Mills, M. Brady, E. J. Ryan, and B. P. Mahon. (1998) 'A respiratory challenge model for infection with Bordetella pertussis: application in the assessment of pertussis vaccine potency and in the definition of the mechanism of protective immunity'. DEVELOPMENTS IN BIOLOGICAL STANDARDISATION, 95 :31-41 [Details]
    1997 'Atypical disease after Bordetella pertussis respiratory infection of mice with targeted disruptions of interferon-γ receptor or imnaunoglobulin μ chain genes'
    Mahon B.;Sheahan B.;Griffin F.;Murphy G.;Mills K. (1997) 'Atypical disease after Bordetella pertussis respiratory infection of mice with targeted disruptions of interferon-γ receptor or imnaunoglobulin μ chain genes'. Journal of Experimental Medicine, 186 (11):1843-1851 [DOI] [full-text] [Details]
    1996 'IL-12 is produced by macrophages in response to live or killed Bordetella pertussis and enhances the efficacy of an acellular pertussis vaccine by promoting the induction of Th1 cells'
    B. P. Mahon, M. Ryan, F. Griffin, P. McGuirk and K. H. G. Mills. (1996) 'IL-12 is produced by macrophages in response to live or killed Bordetella pertussis and enhances the efficacy of an acellular pertussis vaccine by promoting the induction of Th1 cells'. Infection and Immunity, 64 :5295-5301 [full-text] [Details]
    1995 'Poliovirus-specific CD4+ Th1 clones with both cytotoxic and helper activity mediate protective humoral immunity against a lethal poliovirus infection in transgenic mice expressing the human poliovirus receptor'
    B. P. Mahon, K. Katrak, A. Nomoto, A. J. Macadam, P. D. Minor and K. H. G. Mills. (1995) 'Poliovirus-specific CD4+ Th1 clones with both cytotoxic and helper activity mediate protective humoral immunity against a lethal poliovirus infection in transgenic mice expressing the human poliovirus receptor'. Journal of Experimental Medicine, 181 :1285-1292 [full-text] [Details]
    1994 'Immunochemical estimation of haemoglobin types in red blood cells by FACS analysis'
    S.J. Thorpe, S. L. Thein, M. Sampietro, J.E. Craig, B. P. Mahon and E. R. Huehns. (1994) 'Immunochemical estimation of haemoglobin types in red blood cells by FACS analysis'. British Journal of Haematology, 87 :125-131 [Details]
    1992 'Preparative separation of foreign antigens for highly efficient presentation to T cells in vitro'
    K. Katrak, B. P. Mahon, W. C. Jones, S. Brautigam and K. H. G. Mills. (1992) 'Preparative separation of foreign antigens for highly efficient presentation to T cells in vitro'. Journal of Immunological Methods, 156 :247-254 [full-text] [Details]
    1992 'Antigenic sequences of poliovirus recognized by T cells: serotype-specific epitopes on VP1 and VP3 and cross-reactive epitopes on VP4 defined by using CD4+ T-cell clones'
    Mahon BP;Katrak K;Mills KH; (1992) 'Antigenic sequences of poliovirus recognized by T cells: serotype-specific epitopes on VP1 and VP3 and cross-reactive epitopes on VP4 defined by using CD4+ T-cell clones'. Virology, 66 (12) [full-text] [Details]
    1992 'Mechanisms of inhibition of T cell IL-2 secretion by factor VIII concentrates'
    M. Wadwha, P. D. Dilger, J. Tubbs, T. Barrowcliffe, B. P. Mahon and R. Thorpe. (1992) 'Mechanisms of inhibition of T cell IL-2 secretion by factor VIII concentrates'. British Journal of Haematology, 82 :575-583 [Details]
    1991 'Cellular and humoral immune responses to poliovirus in mice: a role for helper T cells in heterotypic immunity to poliovirus'
    K. Katrak, B. P. Mahon, P.D. Minor and K. H. G. Mills. (1991) 'Cellular and humoral immune responses to poliovirus in mice: a role for helper T cells in heterotypic immunity to poliovirus'. Journal of General Virology, 72 :1093-1098 [full-text] [Details]
    1990 'HIV p24-specific helper T cell clones from immunised primates recognise highly conserved regions of HIV-1'
    K. H. G. Mills, P. A. Kitchin, B. P. Mahon, A. L. Barnard, S. E. Adams, M. Kingsman and A. J. Kingsman. (1990) 'HIV p24-specific helper T cell clones from immunised primates recognise highly conserved regions of HIV-1'. Journal of Immunology, 144 :1677-1683 [full-text] [Details]
    1988 'A sensitive and specific immunoradiometric assay (IRMA) for human interleukin-1'
    R. Thorpe, M. Wadwha, A. J. H. Gearing, B. P. Mahon and S. Poole. (1988) 'A sensitive and specific immunoradiometric assay (IRMA) for human interleukin-1'. Lymphokine Research, 7 :119-127 [Details]
    1987 'Preparation and characterisation of monoclonal antibodies directed against antigenic determinants of recombinant human tumour necrosis factor (rTNF)'
    A. Meager, S. Parti, H. Leung, E. Peil and B. P. Mahon. (1987) 'Preparation and characterisation of monoclonal antibodies directed against antigenic determinants of recombinant human tumour necrosis factor (rTNF)'. Hybridoma, 6 :305-311 [full-text] [Details]

    Book Chapters

      Year Publication
    2009 'Tissue Engineering and Regenerative Medicine using Mesenchymal Stem Cells'
    Barry, F.P., Duffy, G., Rooney, G., Mahon, B.P. and Murphy, J.M. (2009) 'Tissue Engineering and Regenerative Medicine using Mesenchymal Stem Cells' In: Regenerative therapy for the musculoskeletal system using recombinant adeno-associated viral vectors. [Details]
    2003 'Cell mediated and humoral immune responses to mumps virus: recent developments'
    M.A. Flynn & B.P. Mahon (2003) 'Cell mediated and humoral immune responses to mumps virus: recent developments' In: Recent research developments in Virology. International: TGN. [full-text] [Details]
    1993 'Cellular and humoral immune responses to poliovirus and tetanus following primary immunisation of SIV-infected Macaques'
    K. H. G. Mills, W. C. Jones, B. P. Mahon, K. Katrak, F. Taffs, E. J. Stott and M. Page. (1993) 'Cellular and humoral immune responses to poliovirus and tetanus following primary immunisation of SIV-infected Macaques' In: Animal models of HIV and other retroviral infections. Basel, Switzerland: Karger. [Details]
    1990 'Titration of SIVmac251 (32H) isolate in cynomolgus macaques for use as a challenge in vaccination studies'
    P.A. Kitchin, M.P. Cranage, N. Almond, A. Barnard, A. Baskerville, T. Corcoran, C. Fromholc, P. Greenaway, C Grief, A. Jenkins, K. Kent, C. Ling, B. P. Mahon, K. Mills, M. Page, P. Silvera, Z. Szotyori, F. Taffs, and E.J. Stott. (1990) 'Titration of SIVmac251 (32H) isolate in cynomolgus macaques for use as a challenge in vaccination studies' In: Animal models in AIDS. Amsterdam: Elsevier Science Publishers B.V.. [Details]
    1990 'Induction of HIV-specific immune responses in primates: fine specificity of antibody and helper T cell recognition of the HIV-p24 protein'
    K. H.G. Mills, A. L. Barnard, B. P. Mahon, P. A. Kitchin, S. E. Adams, M. Kingsman and A. J. Kingsman. (1990) 'Induction of HIV-specific immune responses in primates: fine specificity of antibody and helper T cell recognition of the HIV-p24 protein' In: Vaccines 90: Modern approaches to new vaccines including the prevention of AIDS. New York: Cold Spring Harbor Laboratory. [Details]
    1988 'Monoclonal antibodies to fibrin cross-linked degradation products: comparison of specificities of IgM and IgG classes'
    P. J. Gaffney, L. J. Creighton, A. Curry, B. P. Mahon and R. Thorpe. (1988) 'Monoclonal antibodies to fibrin cross-linked degradation products: comparison of specificities of IgM and IgG classes' In: In Fibrinogen 2. Biochemistry, Physiology and Clinical relevance. Exerpta Medica. Amsterdam: Elsevier. [Details]

    Other Journals

      Year Publication
    2001 'The immunological role of respiratory tract epithelium'
    R. Cunningham and B.P. Mahon. (2001) 'The immunological role of respiratory tract epithelium' Immunology Tools, 1 :204-208. [Details]
    2000 'A brief history of the Irish Society for Immunology (Cumann na hÉireann um Imdhíoneolaíocht)'
    C. O’Farrelly and B. P. Mahon. (2000) 'A brief history of the Irish Society for Immunology (Cumann na hÉireann um Imdhíoneolaíocht)' Immunology Letters, 73 :S47-S47. [full-text] [Details]
    1999 'A personal view of the 10th International Congress of Immunology, New Delhi'
    B. P. Mahon (1999) 'A personal view of the 10th International Congress of Immunology, New Delhi' Immunology News, 6 :22-23. [Details]
    1995 'New generation vaccines-The immune system points the way'
    B. P. Mahon and K. H. G. Mills. (1995) 'New generation vaccines-The immune system points the way' The Irish Scientist, 3 :28-28. [Details]

    Conference Publications

      Year Publication
    2003 Delivery of small interfering RNA to silence immune signaling molecules RNA interference and siRNA
    D. Casey, S. Todryk and B. P. Mahon (2003) Delivery of small interfering RNA to silence immune signaling molecules RNA interference and siRNA Proceedings of Keystone Symposium [Details]
    2002 Does prior Bordetella pertussis infection influence the severity of asthma in a murine model? Rethinking the pathogenesis of asthma
    D. Ennis, J. Cassidy, and B. P. Mahon (2002) Does prior Bordetella pertussis infection influence the severity of asthma in a murine model? Rethinking the pathogenesis of asthma Proceedings of Keystone Symposium [Details]
    1999 Interferon-gamma mediated immune effector mechanisms against Bordetella pertussis
    Mahon B.;Mills K. (1999) Interferon-gamma mediated immune effector mechanisms against Bordetella pertussis Immunology Letters , pp.213-217 [DOI] [Details]
    1997 Mechanisms of immunity to the respiratory pathogen Bordetella pertussis in normal and gene knockout mice: Clearance of primary infection is not enhanced by therapeutic interleukin-12
    Mahon B.;Ryan M.;Griffin F.;Mills K. (1997) Mechanisms of immunity to the respiratory pathogen Bordetella pertussis in normal and gene knockout mice: Clearance of primary infection is not enhanced by therapeutic interleukin-12 Biochemical Society Transactions [Details]

    Conference Contributions

      Year Publication
    2009 Child Innovac (EU).
    (2009) Child Innovac (EU). [Oral Presentation], Preclinical safety of a novel B. pertussis vaccine, Ghent, Belgium [Details]
    2009 5th International Conference on Mesenchymal stem cells.
    (2009) 5th International Conference on Mesenchymal stem cells. [Oral Presentation], MSC: agents of immune modulation, Austin, Texas, USA [Details]
    2009 Annual Conference, Irish Society for Immunology.
    (2009) Annual Conference, Irish Society for Immunology. [Oral Presentation], Mesenchymal Stem cells and immunity, IMM Dublin, Ireland [Details]
    2009 Child Innovac.
    (2009) Child Innovac. [Oral Presentation], Immunity to a novel attenuated whooping cough vaccine, Paris France [Details]
    2009 5th International Conference on Mesenchymal stem cells.
    (2009) 5th International Conference on Mesenchymal stem cells. [Oral Presentation], Panel Expert, Austin, Texas, USA [Details]
    2008 Heinrich-Pette Institute.
    (2008) Heinrich-Pette Institute. [Oral Presentation], Adult mesenchymal stem cells-the immunological ch, Hamburg, Germany [Details]
    2008 British Society for Immunology.
    (2008) British Society for Immunology. [Oral Presentation], Immunological Challenges to mesenchymal stem cell, Glasgow [Details]
    2008 Child Innovac (EU).
    (2008) Child Innovac (EU). [Oral Presentation], Animal models of pertussis vaccine potency assessm, Lille, France [Details]
    2008 Juvenile diabetes research fund.
    (2008) Juvenile diabetes research fund. [Oral Presentation], Therapeutic use of mesenchymal stem cells, New York [Details]
    2008 International Workshop on Stem Cells and Small RNA.
    (2008) International Workshop on Stem Cells and Small RNA. [Oral Presentation], Adult allogeneic MSC therapies, immunological chal, School of Medicine, 2nd Univ of Naples, Italy [Details]
    2008 British Society for oro-maxillo pathology.
    (2008) British Society for oro-maxillo pathology. [Oral Presentation], Adult mesenchymal stem cells-new medicines and cha, Belfast [Details]

    Honours and Awards

      Year Title Awarding Body
    2010 Priz Servier Scholar (Ireland Fund of France)
    1998 Wellcome Trust/HRB New Blood Award

    Professional Associations

      Association Function From / To
    Irish Society of Immunology former National Secretary National Secretary 1999-2002Exec 1996-2003 01-APR-94 / 31-DEC-16
    International Society for Cell Therapy Member 01-APR-09 / 27-APR-16
    Ulster Immunology Group Member 01-APR-94 / 31-DEC-03
    British Society for Immunology Member,Executive of Infection Immunity groupObserver Regional group 12-DEC-87 / 31-DEC-03
    Royal Irish Academy (Committee member) Nat'l committee for Biochemistry 01-SEP-01 / 31-DEC-03

    Committees

      Committee Function From / To
    Research Committee Chair /
    Academic Council Member /
    IUA VP Research Committee Representative /
    Ethics Committee Chair /

    Teaching Interests

    All aspects of Biomedical education at BSc, MSc and PhD level.

    External Collaborators

      Name Role / Description Country
    Prof. Frank Barry. REMEDI, NUI Galway SFI CSET IRELAND
    Prof. Ken Cooke. Cleveland Clinic International U.S.A.
    Prof. Camille Locht. Institut Pasteur de Lille, France Child Innovac FP7 FRANCE