Prof M. Frances Heaney

    Chemistry, Human Health Institute

    Deputy Head of Department

    Science Building
    2.58
    (01) 708 3802

    Biography

    B.Sc. (Hons) Chemistry and Biochemistry; Queen's University Belfast 1986.
    Ph.D. Queen's University Belfast 1990 under the direction of Professor R. Grigg.
    Post doctoral fellow, TCD 1990-1991 in the laboratory of Dr. P. Boyle.
    Junior Lecturer, Chemistry Department, NUI Galway, 1992-1996.
    College Lecturer, Chemistry Department, NUI Galway, 1996-1999.
    Lecturer, Chemistry Department, NUI Maynooth, 1999-2005
    Senior Lecturer NUI Maynooth, 2005-2016
    Professor B, Maynooth University, 2016-

    Book Chapter

    Year Publication
    2022 Frances Heaney, Denise Rooney, Orla Fenelon, Tobias Krämer, Eithne Dempsey, Stephen Barrett, Caytlin Boylan, Kyle Doherty, Luke Marchetti, Joseph Curran, Lisa O’Regan, Trinidad Velasco-Torrijos (2022) 'A Whole Team Approach to Integration of Student Feedback into Continuous Assessment Activities for First-Year Students Transitioning to University Chemistry Education during the COVID-19 Pandemic' In: University Chemistry Teaching in the 21st Century. Ljubljani : Pedagoška fakulteta Univerze v Ljubljani. https://doi.org/10.26529/9789612532970
    2008 Heaney F.; Doyle L. (2008) 'Bicyclic 5-5 systems: Five heteroatoms 2:3 and six heteroatoms 3:3' In: Comprehensive Heterocyclic Chemistry III.
    2005 F. Heaney (2005) 'Thio-, Seleno-, and Telluroacyl Halides' In: A. Padwa(Eds.). Comprehensive Organic Functional Group Transformations II, Vol. 1. Amsterdam : Elsevier.
    1996 F. Heaney (1996) 'Bicyclic 5-5 systems: five heteroatoms 2:3 and six heteroatoms 3:3' In: C.A. Ramsden(Eds.). Comprehensive Heterocyclic Chemistry II, Volume 7. Amsterdam : Elsevier.
    1995 F. Heaney. (1995) 'Functions containing a nitrogen and another group 15 element, Vol. 4' In: A.R. Katritzky and J.K. Taylor(Eds.). Comprehensive Organic Functional Group Transformations. Amsterdam : Elsevier.

    Peer Reviewed Journal

    Year Publication
    2023 Evans, C.; Ahmed, M.; Beirne, D.F.; McCann, M.; Kavanagh, K.; Devereux, M.; Rooney, D.; Heaney, F. (2023) 'Synthesis, characterisation, and solution behaviour of Ag(I) bis(phenanthroline-oxazine) complexes and the evaluation of their biological activity against the pathogenic yeast Candida albicans'. BioMetals, . [Link] [DOI]
    2022 Ahmed, M; Ward, S; McCann, M; Kavanagh, K; Heaney, F; Devereux, M; Twamley, B; Rooney, D (2022) 'Synthesis and characterisation of phenanthroline-oxazine ligands and their Ag(I), Mn(II) and Cu(II) complexes and their evaluation as antibacterial agents'. BioMetals, . [DOI] [Full-Text]
    2021 O’Keeffe, M., Crehan, M., Munro, M., Logan, A., Farrell, A.M., Clarke, E., Flood, M., Ward, M., Andreeva ,T., Van Egeraat, C., Heaney F., Curran, D., Clinton, E. (2021) 'Exploring the role of peer observation of teaching in facilitating cross-institutional professional conversations about teaching and learning'. International Journal for Academic Development, 26 (3):266-278. [DOI] [Full-Text]
    2019 O'Sullivan, Justine; Colleran, John; Twamley, Brendan; Heaney, Frances (2019) 'Highly Selective Fluorimetric Turn-Off Detection of Copper(II) by Two Different Mechanisms in Calix[4]arene-Based Chemosensors and Chemodosimeters'. ChemPlusChem, 84 :1610-1622. [DOI] [Full-Text]
    2015 Maher, NJ; Diao, HW; O'Sullivan, J; Fadda, E; Heaney, F; McGinley, J (2015) 'Lower rim isoxazole-calix[4]arene derivatives as fluorescence sensors for copper(II) ions'. Tetrahedron, 71 :9223-9233. [DOI] [Full-Text]
    2014 Algay V.; O'Sullivan J.; Heaney F. (2014) 'C-3β-tethered functional cholesterol conjugates by nitrile oxide alkyne cycloaddition (NOAC)'. European Journal of Organic Chemistry, 2014 (12):2522-2532. [DOI] [Full-Text]
    2014 Algay, V; O'Sullivan, J; Heaney, F (2014) 'C-3 beta-Tethered Functional Cholesterol Conjugates by Nitrile Oxide Alkyne Cycloaddition (NOAC)'. European Journal of Organic Chemistry, 2014 :2522-2532. [DOI] [Full-Text]
    2013 Freeman, C; Vyle, JS; Heaney, F (2013) 'Oligo switches: photoresponsive oligonucleotide conjugates by solid-supported click chemistry'. RSC Advances, 3 :1652-1655. [DOI] [Full-Text]
    2012 Singh, I; Freeman, C; Madder, A; Vyle, JS; Heaney, F (2012) 'Fast RNA conjugations on solid phase by strain-promoted cycloadditions'. Organic and Biomolecular Chemistry, 10 :6633-6639. [DOI] [Full-Text]
    2012 Heaney, F (2012) 'Nitrile Oxide/Alkyne Cycloadditions - A Credible Platform for Synthesis of Bioinspired Molecules by Metal-Free Molecular Clicking'. European Journal of Organic Chemistry, :3043-3058. [DOI] [Full-Text]
    2011 Singh, I; Zarafshani, Z; Heaney, F; Lutz, JF (2011) 'Orthogonal modification of polymer chain-ends via sequential nitrile oxide-alkyne and azide-alkyne Huisgen cycloadditions'. Polymer Chemistry, 2 :372-375. [DOI] [Full-Text]
    2011 Singh, I; Freeman, C; Heaney, F (2011) 'Efficient Synthesis of DNA Conjugates by Strain-Promoted Azide-Cyclooctyne Cycloaddition in the Solid Phase'. European Journal of Organic Chemistry, :6739-6746. [DOI] [Full-Text]
    2011 Doyle, L; Heaney, F (2011) 'NH-Isoxazolo-bicycles; new molecular scaffolds for organocatalysis'. Tetrahedron, 67 :2132-2138. [DOI] [Full-Text]
    2011 Freeman, C; Cheallaigh, AN; Heaney, F (2011) 'Conjugation at the oligonucleotide level based on isoxazole phosphoramidites generated by click chemistry'. Tetrahedron, 67 :7860-7865. [DOI] [Full-Text]
    2011 Singh, I; Heaney, F (2011) 'Solid phase strain promoted click modification of DNA via [3+2]-nitrile oxide-cyclooctyne cycloadditions'. Chemical Communications, 47 :2706-2708. [DOI] [Full-Text]
    2010 Doyle, L; Heaney, F (2010) 'An investigation of structure-reactivity relationships of delta-alkenyl oximes; competitive thermal reactions leading to cyclic nitrones and/or N-unsubstituted bicyclic isoxazolidines'. Tetrahedron, 66 :7041-7049. [DOI] [Full-Text]
    2010 Singh, I; Heaney, F (2010) 'Metal free, click and click-click conjugation of ribonucleosides and 2 '-OMe oligoribonucleotides on the solid phase'. Organic and Biomolecular Chemistry, 8 :451-456. [DOI] [Full-Text]
    2010 Algay, V; Singh, I; Heaney, F (2010) 'Nucleoside and nucleotide analogues by catalyst free Huisgen nitrile oxide-alkyne 1,3-dipolar cycloaddition'. Organic and Biomolecular Chemistry, 8 :391-397. [DOI] [Full-Text]
    2010 Doyle L.; Heaney F. (2010) 'An investigation of structure-reactivity relationships of δ-alkenyl oximes; Competitive thermal reactions leading to cyclic nitrones and/or N-unsubstituted bicyclic isoxazolidines'. Tetrahedron, 66 (34):7041-7049. [DOI] [Full-Text]
    2009 Singh, I; Vyle, JS; Heaney, F (2009) 'Fast, copper-free click chemistry: a convenient solid-phase approach to oligonucleotide conjugation'. Chemical Communications, :3276-3278. [DOI] [Full-Text]
    2009 Singh, I; Zarafshani, Z; Lutz, JF; Heaney, F (2009) 'Metal-Free Click Chemistry: Efficient Polymer Modification via 1,3-Dipolar Cycloaddition of Nitrile Oxides and Alkynes'. Macromolecules, 42 :5411-5413. [DOI] [Full-Text]
    2007 Heaney, F; Lawless, E (2007) '2-vinyl quinazoline 3-oxides; preparation from acid induced cyclocondensation of 2-acylaminoaryloximes'. Journal of Heterocyclic Chemistry, 44 :569-574. [Full-Text]
    2006 Heaney, F; Lawless, E; Mahon, M; McArdle, P; Cunningham, D (2006) '1,3-Dipolar character of 2-vinyl quinazoline 3-oxides; first and second generation cycloaddition products'. Organic and Biomolecular Chemistry, 4 :2408-2416. [DOI] [Full-Text]
    2005 Heaney, F; McCarthy, T; Mahon, M; McKee, V (2005) 'Bridgehead nitrogen heterocycles which contain the quinazoline moiety - synthesis and cycloaddition of 1,2-dihydroquinazoline 3-oxides'. Organic and Biomolecular Chemistry, 3 :4351-4361. [DOI] [Full-Text]
    2003 Heaney, F; O'Mahony, C; McArdle, P; Cunningham, D (2003) 'Isoxazolo[2,3-d][1,4]benzoxazepine rings from 1,3-dipolar cycloaddition of [1,4]benzoxazepine N-oxides with acetylenic and olefinic dipolarophiles'. Arkivoc, :161-179. [Full-Text]
    2003 Heaney, F; Fenlon, J; McArdle, P; Cunningham, D (2003) 'alpha-Keto amides as precursors to heterocycles-generation and cycloaddition reactions of piperazin-5-one nitrones'. Organic and Biomolecular Chemistry, 1 :1122-1132. [DOI] [Full-Text]
    2003 Heaney, F; Fenlon, J; O'Mahony, C; McArdle, P; Cunningham, D (2003) 'alpha-oximono-esters as precursors to heterocycles - generation of oxazinone N-oxides and cycloaddition to alkene dipolarophiles'. Organic and Biomolecular Chemistry, 1 :4302-4316. [DOI] [Full-Text]
    2003 Heaney F.; Fenlon J.; O'Mahony C.; McArdle P.; Cunningham D. (2003) 'α-oximono-esters as precursors to heterocycles - Generation of oxazinone N-oxides and cycloaddition to alkene dipolarophiles'. Organic and Biomolecular Chemistry, 1 (23):4302-4316. [DOI] [Full-Text]
    2003 Heaney F.; Fenlon J.; McArdle P.; Cunningham D. (2003) 'α-keto amides as precursors to heterocycles - Generation and cycloaddition reactions of piperazin-5-one nitrones'. Organic and Biomolecular Chemistry, 1 (7):1122-1132. [DOI] [Full-Text]
    2001 Heaney, F; Rooney, O; Cunningham, D; McArdle, P (2001) 'Simultaneous double 1,3-dipolar cycloaddition reactions involving bisnitrones or bisdipolarophiles. H-1 NMR investigation of the conformational preferences of N-methyl- and N-phenyl-isoxazolidines'. Journal of the Chemical Society, Perkin Transactions 2, :373-378. [Full-Text]
    2001 O. Rooney, D. Cunningham, P. McArdle (2001) 'Simultaneous Double 1,3-Dipolar Cycloaddition Reactions involving Bisnitrones or Bisdipolarophiles. 1H NMR Investigation of the Conformational Preferences of N-methyl and N-phenyl Isoxazolidines'. Journal of the Chemical Society, Perkin Transactions 2, :373-378. [Full-Text]
    2001 Heaney, F; Burke, C; Cunningham, D; McArdle, P (2001) 'Pyrimidine annelated heterocycles - synthesis and cycloaddition of the first pyrimido[1,4]diazepine N-oxides'. Journal of the Chemical Society, Perkin Transactions 1, :622-632. [Full-Text]
    2001 Heaney, F; Fenlon, J; O'Mahony, C; McArdle, P; Cunningham, D (2001) 'Nitrogen-containing heterocycles: 1,3-dipolar cycloaddition of stabilized nitrones with alkynes; primary cycloadducts, first and second generation rearrangement processes'. Journal of the Chemical Society, Perkin Transactions 1, :3382-3392. [DOI] [Full-Text]
    1999 Frances Heaney, Oliver Rooney, Desmond Cunningham and Patrick McArdle. (1999) 'Site selectivity in the addition of ketoximes to activated allenes and alkynes; N- versus O-alkylation'. Journal of the Chemical Society, Perkin Transactions 1, :143-148. [Full-Text]
    1998 F. Heaney and S. Bourke (1998) 'Nitrogen containing heterocycles from aldoximes; a one-pot route to isoxazolobenzocuazepinones, N-substituted and N-unsubstituted isoxazoloquinolinones'. Journal of the Chemical Society, Perkin Transactions 1, :955-964. [Full-Text]
    1998 F. Heaney, S. Bourke, C. Burke, D. Cmuiingham and P. McArdle (1998) 'Preparation of imidazol[1,2-c]pyrimidinones from a chloropyrimidine and an electron poor w-allylic amine'. Journal of the Chemical Society, Perkin Transactions 1, :2255-2257. [Full-Text]
    1998 F. Heaney and C. O'Mahony (1998) 'The influence of oxime stereochemistry in the generation of nitrones from ro-alkenyloximes by cyclization or 1,2-prototropy'. Journal of the Chemical Society, Perkin Transactions 1, :341-349. [Full-Text]
    1998 F. Heaney, S. Bourke, D. Cunningham and P. McArdle (1998) 'Steric control of reactivity: formation of oximes, benzodiazepinone N-oxides and isoxazoloquinolinones'. Journal of the Chemical Society, Perkin Transactions 2, :547-559. [Full-Text]
    1996 Dr Frances Heaney McKiernan, Margaret T.; (1996) 'Chemoselective formation of symmetrically linked bisisoxazole units: steps toward isoxazoline​/isoxazolidine based macrocycles '. Tetrahedron Letters, 37 :4597-4600. [Full-Text]
    1995 Dr Frances Heaney Bourke, Sharon; (1995) 'The synthesis of 1,​2,​7,​11b-​tetrahydroisoxazolo[2,​3-​d]​[1,​4]​benzodiazepin-​6(5H)​-​ones and 1,​3,​3a,​9b-​tetrahydroisoxazolo[4,​3-​c]​quinolin-​4(5H)​-​ones'. Tetrahedron Letters, 35 :7527-7530. [Full-Text]
    1992 Dr Frances Heaney Ziegler, Irmgard; Borchert, Heaney, Frances; Monika; Davis, Anthony P.; Boyle, Peter H. (1992) 'Structural requirements for the modulatory effect of 6-​substituted pterins on interleukin 2 receptor binding'. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 1135 :330-334.
    1991 Dr Frances Heaney Armstrong, Paul; Grigg, Ronald; Heaney, Frances; Surendrakumar, Sivagnansundram; Warnock, William J. (1991) 'X:Y-​ZH systems as potential 1,​3-​dipoles. Part 33. Generation of nitrones from oximes. Tandem Michael addition-​1,​3-​dipolar cycloaddition reactions. Class 2 processes in which the dipolarophile is located within the oxime'. Tetrahedron, 47 :4495-4518.
    1991 Dr Frances Heaney Grigg, Ronald; Dorrity, Michael J.; Heaney, Frances; Malone, John F.; Rajviroongit, Shuleewan; Sridharan, Visuvanathar; Surendrakumar, Sivagnanasundram (1991) 'X=Y-​ZH systems as potential 1,​3-​dipoles. Part 34. Generation of nitrones from oximes. Tandem Michael addition-​1,​3-​dipolar cycloaddition reactions. Class 2 processes utilizing bifunctional Michael acceptor-​dipolarophile components'. Tetrahedron, 47 :8297-8322.

    Conference Contribution

    Year Publication
    2015 J. W., Hayden, F Heaney (2015) Supramolecular Chemistry Ireland Photoresponsive Carbohydrate Azobenzene Conjugates Maynooth, .
    2015 J O’Sullivan, B Twamley, F Heaney (2015) 13th International Conference on Calixarenes (Calix 2015) Pyrene Functionalised Calixarenes as Metal Sensors Sicily, .
    2014 J O’Sullivan, F Heaney (2014) 66th Irish Universities Chemistry. Research Colloquium Synthesis of Functional Calixarenes for the Selective Detection of Metal Ions Galway, .
    2014 O'Sullivan, Justine; Heaney, Frances (2014) RSC Younger Members Symposium Synthesis of Functional Calixarenes Birmingham, UK, .
    2009 (2009) Click Conjugation of Nucleic Acids UCD Dublin, .
    2009 (2009) Click Chemistry and the RNA Revolution 61st Irish Universities Chemical Research Colloquium .
    2009 Heaney, Frances and Algay, Virginie (2009) Click Chemistry and the RNA Revolution oral DIT, .
    2009 (2009) Microwave Assisted Synthesis of delta2-Isoxazoline and Advances in Synthetic Chemistry Conference Edinburgh, .
    2009 (2009) Microwave Assisted Synthesis of delta-2-Isoxazoline and Isoxazolidine Rings Advances in Synthetic Chemistry Conference Edinburgh, .
    2008 (2008) Metal Free Click Chemistry on Nucleosides and Olig .
    2008 (2008) Click Chemistry and the RNA revolution. Metal and SFI Summit Conference Kilkenny, .
    2008 (2008) A novel click chemistry approach to synthetically 60th Irish Universities Chemistry Research Colloqu UCC, Cork, .
    2008 (2008) Click Chemistry and the RNA Revolution Perspectives on nucleic acid chemistry for therapy Sesimbra, Portugal, .
    2007 (2007) NH-Isoxazolidines-A New Generation of Organocataly Irish Universities Research Chemistry Colloquium Dublin City University, .
    2007 (2007) Organocatalysis with Simple Isoxazolidines 2nd ERA-Chemistry Flash Conference Evora, Portugal, .
    2006 (2006) Oximes as platforms for construction of heterocycl 13th FECHEM Conf. on Heterocycles in Bioorganic Ch Sopron, Hungary, .
    2006 (2006) NH-Isoxazolidines – next generation organocatalyst International Symposium on Organocatalysis in Orga Glasgow, .
    2006 (2006) NH-Isoxazolidines – next generation organocatalyst 58th Irish Universities Chemistry Research Colloqu NUI, Galway, .
    2005 (2005) A comparison of the reactivity of quinazoline 3-ox 11th Blue Danube Conf. on Heterocyclic Chemistry Brno, Czech. Republic, .
    2005 (2005) 2-Vinyl Quinazoline 3-oxides; Preparation and Reac 57th Irish Universities Chemistry Research Colloqu NUI Maynooth, .

    Book Review

    Year Publication
    2012 Heaney, Frances (2012) Nitrile Oxide/Alkyne Cycloadditions - A Credible Platform for Synthesis of Bioinspired Molecules by Metal-Free Molecular Clicking. [Book Review] [DOI]

    Conference Paper

    Year Publication
    2009 Heaney Frances and Algay Virginie (2009) Microwave Assisted Synthesis of delta-2-Isoxazoline and Isoxazolidine Rings. [Conference Paper]
    2009 Heaney Frances, Singh Ishwar and Vyle Joseph (2009) Fast, Copper-Free Click Chemistry, A Convenient Solid-Phase Approach to Oligonucleotide Conjugation. [Conference Paper]

    Editorial

    Year Publication
    2006 Heaney, F; Doyle, L (2006) Discussion of Efficient, microwave-assisted intramolecular 1,3-dipolar cycloadditions of oximes and N-methylnitrones derived from o-alkenylmethoxyacetophenones. OTTAWA: [Editorial] [DOI]

    Thesis

    Year Publication
    1990 F. Heaney (1990) Cycloaddition Reactions of Oximes and Imines. Queen's University Belfast: [Thesis]
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