Dr Martina Schroeder

Biology, Human Health Institute

Senior Lecturer / Associate Professor

(01) 708 6853


2007-2008: Research Lecturer, School of Biochemistry and Immunology, Trinity College Dublin 2003-2007: Postdoctoral Research Fellow, School of Biochemistry and Immunology, Trinity College Dublin (with Prof Andrew Bowie) 1999-2003: PhD Research, Institute of Medical Immunology, Humboldt-University (Charite) Berlin, Germany (with Prof Hans-Dieter Volk).

Research Interests

The Host-Pathogen interaction lab is interested in the recognition of pathogens by the innate immune system, as well as strategies employed by pathogens to evade recognition or to manipulate the ensuing immune response for its own benefit. Viral recognition by the innate immune system is mainly mediated by two classes of pattern recognition receptors: endosomal Toll-like receptors (TLRs) and cytoplasmic RIG-like helicases (RLHs). Both classes detect viral nucleic acids and lead to the induction of type I interferons, which are potent anti-viral mediators. Signalling pathways connecting the anti-viral PRRs to transcription factor activation and interferon induction are beginning to be elucidated, and the lab hopes to contribute to their understanding. A lot of viruses have developed sophisticated mechanism to evade detection by PRRs and/or to actively inhibit the resulting signalling pathways in order to prevent transcription factor activation and the induction of pro-inflammatory and anti-viral mediators. Viral strategies for immune evasion or subversion are optimised during evolution; therefore they tend to target key aspects of the host anti-viral response. Studying the modulation of the host protein by the virus can provide information for the design of anti-viral therapeutics and give us an edge in the evolutionary battle against the virus. Current work in the lab focuses on the human protein DDX3, as three different viruses that pose major global health threats, poxviruses, HIV and HCV, have been shown to manipulate DDX3 function. HIV and HCV seem to require DDX3 for their replication, and it has therefore been proposed as a potential drug target. However, we have recently identified an anti-viral role for DDX3 in type I interferon induction; and DDX3 is also involved in cell growth control. Therefore, we believe that DDX3 function needs to be investigated in more detail before informed strategies for its therapeutic manipulation can be designed.

Peer Reviewed Journal

Year Publication
2022 Pardeshi J.;McCormack N.;Gu L.;Ryan C.S.;Schröder M. (2022) 'DDX3X functionally and physically interacts with Estrogen Receptor-alpha'. Biochimica et Biophysica Acta - Gene Regulatory Mechanisms, 1865 (2). [DOI]
2022 Ryan CS;Schröder M; (2022) 'The human DEAD-box helicase DDX3X as a regulator of mRNA translation'. Frontiers In Cell And Developmental Biology, 10 . [DOI]
2021 Kienes I.;Bauer S.;Gottschild C.;Mirza N.;Pfannstiel J.;Schröder M.;Kufer T.A. (2021) 'DDX3X Links NLRP11 to the Regulation of Type I Interferon Responses and NLRP3 Inflammasome Activation'. Frontiers in Immunology, 12 . [DOI] [Full-Text]
2020 Riva, V;Garbelli, A;Casiraghi, F;Arena, F;Trivisani, CI;Gagliardi, A;Bini, L;Schroeder, M;Maffia, A;Sabbioneda, S;Maga, G (2020) 'Novel alternative ribonucleotide excision repair pathways in human cells by DDX3X and specialized DNA polymerases'. Nucleic Acids Research, 48 :11551-11565. [DOI] [Full-Text]
2019 Kumawat, Lokesh K. and Abogunrin, Anthony A. and Kickham, Michelle and Pardeshi, Jyotsna and Fenelon, Orla and Schroeder, Martina and Elmes, Robert B. P. (2019) 'Squaramide—Naphthalimide Conjugates as “Turn-On” Fluorescent Sensors for Bromide Through an Aggregation-Disaggregation Approach'. 7 . [Link] [DOI] [Full-Text]
2015 Vogel, SZ;Schlickeiser, S;Jurchott, K;Akyuez, L;Schumann, J;Appelt, C;Vogt, K;Schroder, M;Vaeth, M;Berberich-Siebelt, F;Lutz, MB;Grutz, G;Sawitzki, B (2015) 'TCAIM Decreases T Cell Priming Capacity of Dendritic Cells by Inhibiting TLR- Induced Ca2+ Influx and IL-2 Production'. Journal of Immunology, 194 :3136-3146. [DOI] [Full-Text]
2010 Schroder, M (2010) 'Human DEAD-box protein 3 has multiple functions in gene regulation and cell cycle control and is a prime target for viral manipulation'. Biochemical Pharmacology, 79 :297-306. [DOI] [Full-Text]
2009 Oda, S;Schroder, M;Khan, AR (2009) 'Structural Basis for Targeting of Human RNA Helicase DDX3 by Poxvirus Protein K7'. Structure, 17 :1528-1537. [DOI] [Full-Text]
2019 Convery, O;Gargan, S;Kickham, M;Schroder, M;O'Farrelly, C;Stevenson, NJ (2019) 'The hepatitis C virus (HCV) protein, p7, suppresses inflammatory responses to tumor necrosis factor (TNF)-alpha via signal transducer and activator of transcription (STAT)3 and extracellular signal-regulated kinase (ERK)-mediated induction of suppressor of cytokine signaling (SOCS)3'. FASEB Journal, 33 :8732-8744. [DOI] [Full-Text]
2018 Brennan R.;Haap-Hoff A.;Gu L.;Gautier V.;Long A.;Schröder M. (2018) 'Investigating nucleo-cytoplasmic shuttling of the human DEAD-box helicase DDX3'. European Journal of Cell Biology, . [DOI] [Full-Text]
2018 Fullam A;Gu L;Höhn Y;Schröder M; (2018) 'DDX3 directly facilitates IKKα activation and regulates downstream signalling pathways'. Biochemical Journal, 475 (22). [DOI] [Full-Text]
2016 Gu L, Fullam A, McCormack N, Höhn Y, Schröder M. (2016) 'DDX3 directly regulates TRAF3 ubiquitination and acts as a scaffold to co-ordinate assembly of signalling complexes downstream from MAVS'. Biochemical Journal, 474 (4):571-587. [DOI] [Full-Text]
2013 Fullam A, Schroder M (2013) 'DExD/H-box RNA helicases as mediators of anti-viral innate immunity and essential host factors for viral replication'. Biochimica et biophysica acta, 1829 :854-865. [DOI] [Full-Text]
2011 Schroder, Martina (2011) 'Viruses and the human DEAD-box helicase DDX3: inhibition or exploitation?'. Biochemical Society Transactions, 39 :679-683. [Full-Text]
2014 Collins AS, Ahmed S, Napoletano S, Schroeder M, Johnston JA, Hegarty JE, O'Farrelly C, Stevenson NJ (2014) 'Hepatitis C virus (HCV)-induced suppressor of cytokine signaling (SOCS) 3 regulates proinflammatory TNF-α responses'. Journal Of Leukocyte Biology, epub . [Full-Text]
2013 Gu L, Fullam A, Brennan R and Schroder M (2013) 'Human DEAD box helicase 3 couples IκB kinase ε to interferon regulatory factor 3 activation'. Molecular and Cellular Biology, 33 :2004-2015. [DOI] [Full-Text]
2013 Bruni D, Sebastia J, Dunne S, Schroder M, Butler MP (2013) 'A novel IRAK1-IKKε signaling axis limits the activation of TAK1-IKKβ downstream of TLR3'. Journal of Immunology, 190 :2844-2856. [DOI] [Full-Text]
2009 Kalverda AP, Thompson GS, Vogel A, Schröder M, Bowie AG, Khan AR and Homans SW (2009) 'Poxvirus K7 protein adopts a Bcl-2 fold: Biochemical mapping of its interactions with human DEAD-box RNA helicase DDX3'. Molecular Biology, 385 :843-853. [Full-Text]
2009 Naundorf S, Schröder M, Hoflich C, Suman N, Volk HD and Grutz G (2009) 'IL-10 interferes directly with TCR-induced IFN-gamma but not IL-17 production in memory T cells'. European Journal of Immunology, 39 :1066-1077. [Full-Text]
2008 Schröder M, Baran M and Bowie AG (2008) 'Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKe-mediated IRF activation'. EMBO Journal, 27 :2147-2157. [Full-Text]
2007 Schröder M and Bowie AG (2007) 'An arms race: Innate antiviral immune responses and counteracting viral strategies'. Biochemical Society Transactions, 35 :1512-1514.
2006 Carty M, Goodbody R, Schröder M, Stack J, Moynagh PN and Bowie AG (2006) 'The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signalling'. Nature Immunology, 7 :1074-1081. [Full-Text]
2005 Schröder M and Bowie AG (2005) 'TLR3 in anti-viral immunity: key player or bystander?'. Trends in Immunology, 26 :462-468. [Full-Text]
2005 Stack J, Haga IR, Schröder M, Bartlett NW, Maloney G, Reading PC, Fitzgerald KA, Smith GL, Bowie AG (2005) 'Vaccinia Virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence'. Journal of Experimental Medicine, 201 :1007-1018. [Full-Text]
2005 Maloney G, Schroder M, Bowie AG (2005) 'Vaccinia Virus protein A52R activates p38 mitogen-activated protein kinase and potentiates lipopolysaccharide-induced interleukin-10'. 280 :30838-30844. [Full-Text]
2004 Schröder M, Kroeger KM, Volk HD, Eidne KA and Grütz G (2004) 'Preassociation of nonactivated STAT3 molecules demonstrated in living cells using Bioluminescence Resonance Energy Transfer : a new model of STAT activation'. Journal Of Leukocyte Biology, 75 :792-797. [Full-Text]
2003 Schröder M, Meisel C, Buhl K, Profanter N, Sievert N, Volk HD and Grütz G (2003) 'Different modes of IL-10 and TGF-beta to inhibit cytokine-dependent IFN gamma production: nconsequences for reversal of lipopolysaccharide desensitization'. Journal of Immunology, 170 :5260-5267. [Full-Text]

Conference Contribution

Year Publication
2011 (2011) The innate immune function of the  3rd UK and Ireland NF-kB workshop Maynooth, .
2010 (2010) Learning from viruses: 'The role of human DEAD-box helicase 3 in innate immune signalling' Biochemical Society Workshop: Human Disease and Signalling Belfast, NI, .
2010 (2010) The human DEAD-box protein DDX3 is targeted by vaccinia virus to interfere with type I interferon in EMBO workshop ‘Viruses and Innate Immunity’ Dublin, .
2009 (2009) Viral targeting of Human Dead-box protein 3 European Congress of Immunology Berlin, Germany, .
2009 (2009) Human Dead-box protein 3 enhances IFN-b production ISI Annual Conference Dublin, .
2009 (2009) Human DEAD-box protein 3 enhances IFNb production Tri-Society Annual Conference (ICS, ISICR, SLB) Lisbon, Portugal, .
Certain data included herein are derived from the © Web of Science (2023) of Clarivate. All rights reserved.

Professional Associations

Description Function From / To
Irish Society of Immunology Committee member -