Prof Bernard Mahon
Biography
Research
Publications
Professional
Teaching
Biography
My scientific work is based on hypothesis-driven, fundamental studies of murine and human immunology. Two major topics are addressed:
- How do adult mesenchymal stem cells modulate immunity (a question with implications for stem cell therapy, transplantation and tolerance). This work finds application is the design of new cell based therapies;
- The immunology of early life, particularly at the mucosal surface of the airways. This has led me to examine early life infections with the pathogens B. pertussis, poliovirus and B19V, work which has implications for vaccine design, immunisation protocols and diagnostics.
Research Interests
Key Words: Immunology, adult stem cells, cell therapy, vaccines, GvHD, infants, adverse events.My scientific work is based on hypothesis-driven, fundamental studies of murine and human immunology. Two major topics are addressed:
- How do adult mesenchymal stem cells modulate immunity? (a question with implications for stem cell therapy, transplantation and tolerance). This work finds application is the design of new cell based therapies;
- The immunology of early life, particularly at the mucosal surface of the airways. This has led me to examine early life infections with the pathogens B. pertussis, poliovirus and B19V, work which has implications for vaccine design, immunisation protocols and diagnostics.
Peer Reviewed Journal
| Year | Publication | |
|---|---|---|
| 2017 | Carty, F; Mahon, BP; English, K (2017) 'The influence of macrophages on mesenchymal stromal cell therapy: passive or aggressive agents?'. Clinical and Experimental Immunology, 188 :1-11. [DOI] [Full-Text] | |
| 2016 | Kennelly, H; Mahon, BP; English, K (2016) 'Human mesenchymal stromal cells exert HGF dependent cytoprotective effects in a human relevant pre-clinical model of COPD'. Scientific Reports, 6 . [DOI] [Full-Text] | |
| 2011 | Scanlon, KM; Hawksworth, RJ; Lane, SJ; Mahon, BP (2011) 'IL-17A Induces CCL28, Supporting the Chemotaxis of IgE-Secreting B Cells'. International Archives of Allergy and Immunology, 156 :51-61. [DOI] | |
| 2008 | Skerry, CM; Locht, C; Mahon, B (2008) 'The absence of specific virulence factors in a live attenuated Bordetella pertussis candidate vaccine strain ablates atypical pathologies in IFN-gamma R knockout mice'. Journal of Immunology, 125 :141-142. | |
| 1998 | Mahon B.; Moore A.; Johnson P.; Mills K. (1998) 'Approaches to new vaccines'. Critical Reviews in Biotechnology, 18 (4):257-282. [DOI] | |
| 1998 | Brady M.; Mahon B.; Mills K. (1998) 'Pertussis infection and vaccination induces Th1 cells [2]'. Immunology Today, 19 (11). [DOI] [Full-Text] | |
| 1998 | Coakley R.; O'Neill S.; Coakley R.; Glynn P.; O'Neill S.; Finlay G.; Russell K.; McMahon K.; D'Arcy E.; Masterson J.; Fitzgerald M.; O'Connor C.; O'Driscoll L.; Finlay G.; Fitzgerald M.; O'Connor C.; McGarvey L.; Forsythe P.; Heaney L.; MacMahon J.; Ennis M.; Leonard C.; Tormey V.; Burke C.; Poulter L.; Keatings V.; FitzGerald M.; Barnes P.; Harty H.; Corfield D.; Adams L.; Schwartzstein R.; Kiely J.; Buckley A.; Shiels P.; Deegan P.; Maurer B.; McNicholas W.; Dunlop K.; Martin B.; Riley M.; Shields M.; Glynn P.; Kilgallen I.; Coakley R.; O'Neill S.; McElvaney N.; Cervantes-Laurean D.; Wehr N.; Gabriele K.; Robinson W.; Moss J.; Levine R.; Urbach V.; Walsh D.; Harvey B.; McElroy M.; Pittet J.; Allen L.; Wiener-Kroonish J.; Dobbs L.; O'Donnell D.; McMahon K.; O'Connor C.; Fitzgerald M.; McGuirk P.; Mahon B.; Griffin F.; Mills K.; Murphy R.; Brijker F.; Mulloy E.; Cohen Tervaert J.; Walshe J.; O'Neill S.; McGarvey L.; Heaney L.; Lowry R.; Shepherd D.; MacMahon J. (1998) 'Irish thoracic society - Proceeds of annual scientific meeting held Friday & Saturday 8th & 9th November, 1996'. Irish Journal of Medical Science, 167 (9 Supplement):1-13. [DOI] [Full-Text] | |
| 1998 | Mills K.; Brady M.; Ryan E.; Mahon B. (1998) 'A respiratory challenge model for infection with Bordetella pertussis: application in the assessment of pertussis vaccine potency and in defining the mechanism of protective immunity'. Developments in Biological Standardization, 95 :31-41. | |
| 1996 | Conway, M; Mahon, B; Mills, KHG (1996) 'CD4(+) MHC class II-restricted Th1 clones specific for poliovirus induce apoptosis in B cells: Implications for their cytolytic and helper functions'. Journal of Immunology, 89 :174-174. | |
| 2016 | McClean S; Healy ME; Collins C; Carberry S; O'Shaughnessy L; Dennehy R; Adams Á; Kennelly H; Corbett JM; Carty F; Cahill LA; Callaghan M; English K; Mahon BP; Doyle S; Shinoy M; (2016) 'Linocin and OmpW Are Involved in Attachment of the Cystic Fibrosis-Associated Pathogen Burkholderia cepacia Complex to Lung Epithelial Cells and Protect Mice against Infection'. Infection and Immunity, 84 (5). [DOI] [Full-Text] | |
| 2016 | Cahill EF; Kennelly H; Carty F; Mahon BP; English K; (2016) 'Hepatocyte Growth Factor Is Required for Mesenchymal Stromal Cell Protection Against Bleomycin-Induced Pulmonary Fibrosis'. Stem cells translational medicine, 5 (10). [DOI] [Full-Text] | |
| 2005 | Ryan J.; Barry F.; Murphy J.; Mahon B. (2005) 'Mesenchymal stem cells avoid allogeneic rejection'. JOURNAL OF INFLAMMATION, 2 . [DOI] [Full-Text] | |
| 2015 | Cahill E.; Tobin L.; Carty F.; Mahon B.; English K. (2015) 'Jagged-1 is required for the expansion of CD4+ CD25+ FoxP3+ regulatory T cells and tolerogenic dendritic cells by murine mesenchymal stromal cells'. Stem Cell Research and Therapy, 6 (1). [DOI] [Full-Text] | |
| 2013 | Noone C.; Kihm A.; English K.; O'Dea S.; Mahon B. (2013) 'IFN-gamma stimulated human umbilical-tissue-derived cells potently suppress NK activation and resist NK-mediated cytotoxicity in vitro'. Stem Cells and Development, 22 (22):3003-3014. [DOI] [Full-Text] | |
| 2013 | Franquesa, M; Hoogduijn, MJ; Reinders, ME; Eggenhofer, E; Engela, AU; Mensah, FK; Torras, J; Pileggi, A; van Kooten, C; Mahon, B; Detry, O; Popp, FC; Benseler, V; Casiraghi, F; Johnson, C; Ancans, J; Fillenberg, B; delaRosa, O; Aran, JM; Roemeling-vanRhijn, M; Pinxteren, J; Perico, N; Gotti, E; Christ, B; Reading, J; Introna, M; Deans, R; Shagidulin, M; Farre, R; Rambaldi, A; Sanchez-Fueyo, A; Obermajer, N; Pulin, A; Dor, FJMF; Portero-Sanchez, I; Baan, CC; Rabelink, TJ; Remuzzi, G; Betjes, MGH; Dahlke, MH; Grinyo, JM (2013) 'Mesenchymal Stem Cells in Solid Organ Transplantation (MiSOT) Fourth Meeting: Lessons Learned from First Clinical Trials'. Transplantation, 96 :234-238. [DOI] [Full-Text] | |
| 2011 | Kavanagh H.; Mahon B. (2011) 'Allogeneic mesenchymal stem cells prevent allergic airway inflammation by inducing murine regulatory T cells'. Allergy: European Journal of Allergy and Clinical Immunology, 66 (4):523-531. [DOI] [Full-Text] | |
| 2010 | Kavanagh H., and B.P. Mahon. (2010) 'Adult Mesenchymal Stem Cells - Intelligent therapies for immune reprogramming'. International Drug Discovery, 5 :46-51. | |
| 2010 | Griffin MD, Ritter T, and B.P. Mahon (2010) 'Immunological Aspects of Allogeneic Mesenchymal Stem Cell Therapies'. Human Gene Therapy, 21 :1641-1655. [DOI] [Full-Text] | |
| 2010 | Kavanagh H, English K, Locht C, and B.P. Mahon. (2010) 'The attenuated Bordetella pertussis vaccine strain BPZE1 prevents exacerbated allergic pathology in a murine model'. Clinical and Experimental Allergy, 40 :933-941. [Full-Text] | |
| 2010 | Coughlan, A., K. Scanlon, B.P. Mahon & M.R. Towler. (2010) 'Zinc and Silver Glass Polyalkenoate Cement Solutions: An Evaluation of their Antibacterial Nature Through in vitro and in vivo Testing'. Bio-Medical Materials and Engineering, 20 :99-106. [Full-Text] | |
| 2009 | English, K., J.R. Ryan, L. Tobin, M.J. Murphy, F.P. Barry and B.P. Mahon. (2009) 'Cell Contact, Prostaglandin E2 and Transforming growth factor beta 1 play non redundant roles in Human Mesenchymal Stem Cell Induction of CD4+CD25HighFoxp3+ Regulatory T cells'. Clinical and Experimental Immunology, 156 :149-160. [DOI] [Full-Text] | |
| 2008 | K. English, F. P. Barry and B. P. Mahon. (2008) 'Murine mesenchymal stem cells suppress dendritic cell migration, maturation and function'. Immunology Letters, 115 :50-58. [Full-Text] | |
| 2008 | McGauran, A.T., J.B. Moore, D. Madsen, D. Barry, S. O’Dea, B.P. Mahon and S. Commins (2008) 'A possible role for protein synthesis, ERK and BDNF in long-term spatial memory retention in the water maze'. Behavioral Neuroscience, 122 :805-815. [Full-Text] | |
| 2007 | English K.; Barry F.; Field-Corbett C.; Mahon B. (2007) 'IFN-g and TNF-a differentially regulate immunomodulation by murine mesenchymal stem cells'. Immunology Letters, 110 (2):91-100. [DOI] [Full-Text] | |
| 2006 | Harvey, D; Smith, R; English, K; Mahon, B; Commins, S (2006) 'Interleukin-10 (IL-10) but not Lipopolysaccharide (LPS) produces increased motor activity and abnormal exploratory patterns while impairing spatial learning in Balb/c mice'. Physiology and Behavior, 87 :842-847. [DOI] [Full-Text] | |
| 2005 | D.P. Ennis, J.P. Cassidy, and B.P. Mahon. (2005) 'Whole cell pertussis vaccine protects against Bordetella pertussis exacerbation of allergic asthma: Pw immunization reduces IL-13 and IL-10'. Immunology Letters, 97 :91-100. [Full-Text] | |
| 2005 | O'Gorman M.; Jatoi N.; Lane S.; Mahon B. (2005) 'IL-1beta and TNF-alpha induce increased expression of CCL28 by airway epithelial cells via an NFκB-dependent pathway'. Cellular Immunology, 238 (2):87-96. [DOI] [Full-Text] | |
| 2005 | F. P. Barry, J. M. Murphy, T. O’Brien and B. P. Mahon (2005) 'Mesenchymal Stem Cell Transplantation for Tissue Repair'. Seminars in Plastic Surgery, 19 :229-240. [Full-Text] | |
| 2005 | F.P. Barry, J.M. Murphy, K. English and B.P. Mahon. (2005) 'Immunogenicity of adult mesenchymal stem cells: lessons from the fetal allograft. '. Stem Cells and Development, 14 :252-265. [Full-Text] | |
| 2005 | C.M. Noone, A.B. Frawely, M.F. Doyle, B.P. Mahon, K.H.G. Mills and. P.A. Johnson. (2005) 'Novel mechanism of immunosuppression by influenza virus haemagglutinin: selective suppression of IL-12p35 transcription'. Journal of General Virology, 86 :1885-1890. [Full-Text] | |
| 2005 | D. P. Ennis, J. P. Cassidy, and B. P. Mahon. (2005) 'Acellular pertussis vaccine protects against Bordetella pertussis exacerbation of allergic asthma but in the absence of infection potentiates airway IL-10 and IL-13'. Clinical and Diagnostic Laboratory Immunology, 12 :409-417. [Full-Text] | |
| 2004 | Flynn M.; Casey D.; Todryk S.; Mahon B. (2004) 'Efficient delivery of small interfering RNA for inhibition of IL-12p40 expression in vivo'. Journal of Inflammation, 1 . [DOI] [Full-Text] | |
| 2004 | A. Corcoran, B. P. Mahon and S. Doyle. (2004) 'B cell memory is directed towards conformational epitopes of parvovirus B19 capsid proteins and the VP1-unique region. Journal of Infectious Diseases. 189:1873-1880'. Journal of Infectious Diseases, 183 :1873-1880. [Full-Text] | |
| 2004 | D. P. Ennis, J. P. Cassidy, and B. P. Mahon. (2004) 'Prior Bordetella pertussis infection influences allergen priming and the severity of airway pathology in a murine model of allergic asthma'. Clinical and Experimental Allergy, 34 :1488-1497. [Full-Text] | |
| 2004 | M. Flynn, D. Casey. S. Todryk, and B. P. Mahon (2004) 'Efficient delivery of small interfering RNA for inhibition of IL-12p40 expression in vivo. '. 1 :1-12. [Full-Text] | |
| 2002 | Daly P.; Corcoran A.; Mahon B.; Doyle S. (2002) 'High-sensitivity PCR detection of parvovirus B19 in plasma'. Journal of Clinical Microbiology, 40 (6):1958-1962. [DOI] [Full-Text] | |
| 2001 | R. Cunningham and B. P. Mahon (2001) 'The immunological role of respiratory tract epithelium'. Modern Aspects of Immunobiology, 1 :204-208. | |
| 2001 | Mahon B. (2001) 'The rational design of vaccine adjuvants for mucosal and neonatal immunization'. Current Medicinal Chemistry, 8 (9):1057-1075. | |
| 2000 | B. P. Mahon, M. T. Brady and K. H. G. Mills. (2000) 'Protection against Bordetella pertussis in mice in the absence of circulating antibody: Implications for long term immunity in children'. Journal of Infectious Diseases, 181 :2087-2091. [Full-Text] | |
| 2000 | A. Corcoran, S. Doyle, D. Waldron, A. Nicholson, and B. P. Mahon. (2000) 'Impaired interferon-g responses against Parvovirus B19 by recently infected children'. JOURNAL OF VIROLOGY, 74 :9903-9910. [Full-Text] | |
| 2000 | Mahon B.; Brady M.; Mills K. (2000) 'Protection against Bordetella pertussis in mice in the absence of detectable circulating antibody: Implications for long-term immunity in children'. Journal of Infectious Diseases, 181 (6):2087-2091. [DOI] [Full-Text] | |
| 1999 | M. Brady, B. P. Mahon, and K. H. G. Mills. (1999) 'Pertussis infection and vaccination induce Th1 cells and does not enhance allergy'. Trends in Immunology, 19 :534-534. | |
| 1999 | B. P. Mahon, and K. H. G. Mills. (1999) 'Interferon-g mediated immune effector mechanisms against Bordetella pertussis'. Immunology Letters, 68 :213-217. [Full-Text] | |
| 1999 | Mills, KHG; Ryan, M; McGuirk, P; Griffin, F; Murphy, G; Mahon, B (1999) 'The immunology of Bordetella pertussis infection'. Biologicals, 27 :77-77. [Full-Text] | |
| 1998 | M. Ryan, L. McCarthy, B. P. Mahon, R. Rappuoli, and K. H. G. Mills. (1998) 'PT potentiates Th1 and Th2 responses to co-injected antigen: adjuvant action is associated with enhanced regulatory cytokine production and expression of the co-stimulatory molecules B7-1, B7-2 and CD28'. International Immunology, 10 :651-662. [Full-Text] | |
| 1998 | K. H. G. Mills, M. Brady, E. J. Ryan, and B. P. Mahon. (1998) 'A respiratory challenge model for infection with Bordetella pertussis: application in the assessment of pertussis vaccine potency and in the definition of the mechanism of protective immunity'. DEVELOPMENTS IN BIOLOGICAL STANDARDISATION, 95 :31-41. | |
| 1997 | Mahon B.; Sheahan B.; Griffin F.; Murphy G.; Mills K. (1997) 'Atypical disease after Bordetella pertussis respiratory infection of mice with targeted disruptions of interferon-γ receptor or imnaunoglobulin μ chain genes'. Journal of Experimental Medicine, 186 (11):1843-1851. [DOI] [Full-Text] | |
| 1996 | B. P. Mahon, M. Ryan, F. Griffin, P. McGuirk and K. H. G. Mills. (1996) 'IL-12 is produced by macrophages in response to live or killed Bordetella pertussis and enhances the efficacy of an acellular pertussis vaccine by promoting the induction of Th1 cells'. Infection and Immunity, 64 :5295-5301. [Full-Text] | |
| 1995 | B. P. Mahon, K. Katrak, A. Nomoto, A. J. Macadam, P. D. Minor and K. H. G. Mills. (1995) 'Poliovirus-specific CD4+ Th1 clones with both cytotoxic and helper activity mediate protective humoral immunity against a lethal poliovirus infection in transgenic mice expressing the human poliovirus receptor'. Journal of Experimental Medicine, 181 :1285-1292. [Full-Text] | |
| 1994 | S.J. Thorpe, S. L. Thein, M. Sampietro, J.E. Craig, B. P. Mahon and E. R. Huehns. (1994) 'Immunochemical estimation of haemoglobin types in red blood cells by FACS analysis'. British Journal of Haematology, 87 :125-131. | |
| 1992 | K. Katrak, B. P. Mahon, W. C. Jones, S. Brautigam and K. H. G. Mills. (1992) 'Preparative separation of foreign antigens for highly efficient presentation to T cells in vitro'. Journal of Immunological Methods, 156 :247-254. [Full-Text] | |
| 1992 | Mahon BP; Katrak K; Mills KH; (1992) 'Antigenic sequences of poliovirus recognized by T cells: serotype-specific epitopes on VP1 and VP3 and cross-reactive epitopes on VP4 defined by using CD4+ T-cell clones'. Virology, 66 (12). [Full-Text] | |
| 1992 | M. Wadwha, P. D. Dilger, J. Tubbs, T. Barrowcliffe, B. P. Mahon and R. Thorpe. (1992) 'Mechanisms of inhibition of T cell IL-2 secretion by factor VIII concentrates'. British Journal of Haematology, 82 :575-583. | |
| 1991 | K. Katrak, B. P. Mahon, P.D. Minor and K. H. G. Mills. (1991) 'Cellular and humoral immune responses to poliovirus in mice: a role for helper T cells in heterotypic immunity to poliovirus'. Journal of General Virology, 72 :1093-1098. [Full-Text] | |
| 1990 | K. H. G. Mills, P. A. Kitchin, B. P. Mahon, A. L. Barnard, S. E. Adams, M. Kingsman and A. J. Kingsman. (1990) 'HIV p24-specific helper T cell clones from immunised primates recognise highly conserved regions of HIV-1'. Journal of Immunology, 144 :1677-1683. [Full-Text] | |
| 1988 | R. Thorpe, M. Wadwha, A. J. H. Gearing, B. P. Mahon and S. Poole. (1988) 'A sensitive and specific immunoradiometric assay (IRMA) for human interleukin-1'. Lymphokine Research, 7 :119-127. | |
| 1987 | A. Meager, S. Parti, H. Leung, E. Peil and B. P. Mahon. (1987) 'Preparation and characterisation of monoclonal antibodies directed against antigenic determinants of recombinant human tumour necrosis factor (rTNF)'. Hybridoma, 6 :305-311. [Full-Text] |
Book Chapter
| Year | Publication | |
|---|---|---|
| 2009 | Barry, F.P., Duffy, G., Rooney, G., Mahon, B.P. and Murphy, J.M. (2009) 'Tissue Engineering and Regenerative Medicine using Mesenchymal Stem Cells' In: Regenerative therapy for the musculoskeletal system using recombinant adeno-associated viral vectors. | |
| 2003 | M.A. Flynn & B.P. Mahon (2003) 'Cell mediated and humoral immune responses to mumps virus: recent developments' In: Recent research developments in Virology. International : TGN. [Full-Text] | |
| 1993 | K. H. G. Mills, W. C. Jones, B. P. Mahon, K. Katrak, F. Taffs, E. J. Stott and M. Page. (1993) 'Cellular and humoral immune responses to poliovirus and tetanus following primary immunisation of SIV-infected Macaques' In: P. Racz, N.L. Letvin and J.C. Gluckman(Eds.). Animal models of HIV and other retroviral infections. Basel, Switzerland : Karger. | |
| 1990 | P.A. Kitchin, M.P. Cranage, N. Almond, A. Barnard, A. Baskerville, T. Corcoran, C. Fromholc, P. Greenaway, C Grief, A. Jenkins, K. Kent, C. Ling, B. P. Mahon, K. Mills, M. Page, P. Silvera, Z. Szotyori, F. Taffs, and E.J. Stott. (1990) 'Titration of SIVmac251 (32H) isolate in cynomolgus macaques for use as a challenge in vaccination studies' In: H. Schellekens and M.C. Horzinek (Eds)(Eds.). Animal models in AIDS. Amsterdam : Elsevier Science Publishers B.V.. | |
| 1990 | K. H.G. Mills, A. L. Barnard, B. P. Mahon, P. A. Kitchin, S. E. Adams, M. Kingsman and A. J. Kingsman. (1990) 'Induction of HIV-specific immune responses in primates: fine specificity of antibody and helper T cell recognition of the HIV-p24 protein' In: F. Brown, R. Chanock, H.S. Ginsberg and R. Lerner(Eds.). Vaccines 90: Modern approaches to new vaccines including the prevention of AIDS. New York : Cold Spring Harbor Laboratory. | |
| 1988 | P. J. Gaffney, L. J. Creighton, A. Curry, B. P. Mahon and R. Thorpe. (1988) 'Monoclonal antibodies to fibrin cross-linked degradation products: comparison of specificities of IgM and IgG classes' In: Lowe, J.D.O(Eds.). In Fibrinogen 2. Biochemistry, Physiology and Clinical relevance. Exerpta Medica. Amsterdam : Elsevier. |
Other Journal
| Year | Publication | |
|---|---|---|
| 2001 | R. Cunningham and B.P. Mahon. (2001) 'The immunological role of respiratory tract epithelium' Immunology Tools, 1 :204-208. | |
| 2000 | C. O’Farrelly and B. P. Mahon. (2000) 'A brief history of the Irish Society for Immunology (Cumann na hÉireann um Imdhíoneolaíocht)' Immunology Letters, 73 :S47-S47. [Full-Text] | |
| 1999 | B. P. Mahon (1999) 'A personal view of the 10th International Congress of Immunology, New Delhi' Immunology News, 6 :22-23. | |
| 1995 | B. P. Mahon and K. H. G. Mills. (1995) 'New generation vaccines-The immune system points the way' The Irish Scientist, 3 :28-28. |
Conference Publication
| Year | Publication | |
|---|---|---|
| 2003 | D. Casey, S. Todryk and B. P. Mahon (2003) Proceedings of Keystone Symposium Delivery of small interfering RNA to silence immune signaling molecules RNA interference and siRNA | |
| 2002 | D. Ennis, J. Cassidy, and B. P. Mahon (2002) Proceedings of Keystone Symposium Does prior Bordetella pertussis infection influence the severity of asthma in a murine model? Rethinking the pathogenesis of asthma | |
| 1999 | Mahon B.; Mills K. (1999) Immunology Letters Interferon-gamma mediated immune effector mechanisms against Bordetella pertussis [DOI] | |
| 1997 | Mahon B.; Ryan M.; Griffin F.; Mills K. (1997) Biochemical Society Transactions Mechanisms of immunity to the respiratory pathogen Bordetella pertussis in normal and gene knockout mice: Clearance of primary infection is not enhanced by therapeutic interleukin-12 |
Conference Contribution
Certain data included herein are derived from the © Web of Science (2023) of Clarivate. All rights reserved.
Professional Associations
Teaching Interests
All aspects of Biomedical education at BSc, MSc and PhD level.