Dr Joanne Masterson
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Biography
Joanne Masterson, PhD obtained her BSc and PhD degrees from Maynooth University. She subsequently moved abroad to complete her postdoctoral training and fellowships (2014) and became an Assistant Professor at the University of Colorado Denver, Colorado, USA. She was appointed Assistant Professor in Maynooth University’s Department of Biology in 2018, is the Principal Investigator of the Allergy, Inflammation and Remodelling Research (AIRR) lab and is a member of the Kathleen Lonsdale Institute for Human Health Research. In 2019 Dr Masterson was awarded the Science Foundation President of Ireland Future Research Leaders Award.
Research Interests
Joanne
Masterson, PhD is the Principal Investigator of the Allergy, Inflammation
and Remodeling Research (AIRR) lab. She has a long-standing interest in
defining novel mechanisms of mucosal inflammation. Her research has investigated the
eosinophils contribution to epithelial cell biology and tissue remodeling. Her studies have identified novel mechanisms,
that include oxygen sensing and metabolism, hypoxia and novel cytokine mediators through which allergic and mucosal diseases such as Eosinophilic Esophagitis
(EoE) and Inflammatory Bowel Disease (IBD) develop.
Research Projects
Post Doctoral Fellows / Research Team
Book
Other Publication
Year | Publication | |
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2023 | Markey, G.E.; Donohoe, C.L.; McNamee, E.N.; Masterson, J.C. (2023) MicroRNA dysregulation and therapeutic opportunities in esophageal diseases. [Link] [DOI] | |
2023 | Menard-Katcher, C.; Liu, C.; Galbraith, M.D.; Benson, T.; Burger, C.; Dobias, D.; Larsen, L.; O'Brien, C.; Spencer, L.A.; Furuta, G.T.; Masterson, J.C. (2023) Fibrostenotic eosinophilic esophagitis phenotype is defined by a proliferative gene signature. [Link] [DOI] |
Peer Reviewed Journal
Year | Publication | |
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2024 | Markey, G.E.; Ryan, S.; Furuta, G.T.; Menard-Katcher, C.; McNamee, E.N.; Masterson, J.C. (2024) 'Hypoxia-inducible microRNA-155 negatively regulates epithelial barrier in eosinophilic esophagitis by suppressing tight junction claudin-7'. FASEB Journal, 38 . [Link] [DOI] | |
2023 | Phelan, D.E.; Mota, C.; Strowitzki, M.J.; Shigemura, M.; Sznajder, J.I.; Crowe, L.; Masterson, J.C.; Hayes, S.E.; Reddan, B.; Yin, X.; Brennan, L.; Crean, D.; Cummins, E.P. (2023) 'Hypercapnia alters mitochondrial gene expression and acylcarnitine production in monocytes'. Immunology and Cell Biology, . [Link] [DOI] | |
2023 | Gallagher, C.; Mahon, J.M.; O'Neill, C.; Cassidy, F.C.; Dunbar, H.; De Barra, C.; Cadden, C.; Pisarska, M.M.; Wood, N.A.W.; Masterson, J.C.; McNamee, E.N.; Schrumpf, E.; English, K.; O'Shea, D.; Tobin, A.M.; Hogan, A.E. (2023) 'Mucosal-Associated Invariant T Cells Are Altered in Patients with Hidradenitis Suppurativa and Contribute to the Inflammatory Milieu'. Journal of Investigative Dermatology, . [Link] [DOI] | |
2021 | Ma C; Schoepfer AM; Safroneeva E; ; ; (2021) 'Development of a Core Outcome Set for Therapeutic Studies in Eosinophilic Esophagitis (COREOS): An International Multidisciplinary Consensus'. Journal of Gastroenterology, 161 (3). [DOI] [Full-Text] | |
2021 | Ma C.; Schoepfer A.M.; Dellon E.S.; Bredenoord A.J.; Chehade M.; Collins M.H.; Feagan B.G.; Furuta G.T.; Gupta S.K.; Hirano I.; Jairath V.; Katzka D.A.; Pai R.K.; Rothenberg M.E.; Straumann A.; Aceves S.S.; Alexander J.A.; Arva N.C.; Atkins D.; Biedermann L.; Blanchard C.; Cianferoni A.; Ciriza de los Rios C.; Clayton F.; Davis C.M.; de Bortoli N.; Dias J.A.; Falk G.W.; Genta R.M.; Ghaffari G.; Gonsalves N.; Greuter T.; Hopp R.; Hsu Blatman K.S.; Jensen E.T.; Johnston D.; Kagalwalla A.F.; Larsson H.M.; Leung J.; Louis H.; Masterson J.C.; Menard-Katcher C.; Menard-Katcher P.A.; Moawad F.J.; Muir A.B.; Mukkada V.A.; Penagini R.; Pesek R.D.; Peterson K.; Putnam P.E.; Ravelli A.; Savarino E.V.; Schlag C.; Schreiner P.; Simon D.; Smyrk T.C.; Spergel J.M.; Taft T.H.; Terreehorst I.; Vanuytsel T.; Venter C.; Vieira M.C.; Vieth M.; Vlieg-Boerstra B.; von Arnim U.; Walker M.M.; Wechsler J.B.; Woodland P.; Woosley J.T.; Yang G.Y.; Zevit N.; Safroneeva E. (2021) 'Development of a core outcome set for therapeutic studies in eosinophilic esophagitis (COREOS)'. Journal of Allergy and Clinical Immunology, . [DOI] [Full-Text] | |
2021 | Ma C; Schoepfer AM; Safroneeva E; ; (2021) 'A Summary of the Meetings of the Development of a Core Outcome Set for Therapeutic Studies in Eosinophilic Esophagitis (COREOS) International Multidisciplinary Consensus'. Journal of Gastroenterology, 161 (3). [DOI] [Full-Text] | |
2021 | Masterson JC; Menard-Katcher C; Larsen LD; Furuta GT; Spencer LA; (2021) 'Heterogeneity of Intestinal Tissue Eosinophils: Potential Considerations for Next-Generation Eosinophil-Targeting Strategies'. Cells, 10 (2). [DOI] [Full-Text] | |
2019 | Masterson JC; Biette KA; Hammer JA; Nguyen N; Capocelli KE; Saeedi BJ; Harris RF; Fernando SD; Hosford LB; Kelly CJ; Campbell EL; Ehrentraut SF; Ahmed FN; Nakagawa H; Lee JJ; McNamee EN; Glover LE; Colgan SP; Furuta GT; (2019) 'Epithelial HIF-1α/claudin-1 axis regulates barrier dysfunction in eosinophilic esophagitis'. Journal of Clinical Investigation, 129 (8). [DOI] [Full-Text] | |
2017 | Neudecker, V; Haneklaus, M; Jensen, O; Khailova, L; Masterson, JC; Tye, H; Biette, K; Jedlicka, P; Brodsky, KS; Gerich, ME; Mack, M; Robertson, AAB; Cooper, MA; Furuta, GT; Dinarello, CA; O'Neill, LA; Eltzschig, HK; Masters, SL; McNamee, EN (2017) 'Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome'. Journal of Experimental Medicine, 214 :1737-1752. [DOI] [Full-Text] | |
2019 | Nguyen N; Baumgarten A; Wright BL; Capocelli KE; Pan Z; Lee JJ; Furuta GT; Masterson JC; (2019) 'Histologic similarities in children with eosinophilic esophagitis and proton pump inhibitor-responsive esophageal eosinophilia'. Journal of Allergy and Clinical Immunology, 143 (3). [DOI] [Full-Text] | |
2019 | Ackerman SJ; Kagalwalla AF; Hirano I; Gonsalves N; Katcher PM; Gupta S; Wechsler JB; Grozdanovic M; Pan Z; Masterson JC; Du J; Fantus RJ; Alumkal P; Lee JJ; Ochkur S; Ahmed F; Capocelli K; Melin-Aldana H; Biette K; Dubner A; Amsden K; Keeley K; Sulkowski M; Zalewski A; Atkins D; Furuta GT; (2019) 'One-Hour Esophageal String Test: A Nonendoscopic Minimally Invasive Test That Accurately Detects Disease Activity in Eosinophilic Esophagitis'. American Journal of Gastroenterology, 114 (10). [DOI] [Full-Text] | |
2019 | Grozdanovic M; Laffey KG; Abdelkarim H; Hitchinson B; Harijith A; Moon HG; Park GY; Rousslang LK; Masterson JC; Furuta GT; Tarasova NI; Gaponenko V; Ackerman SJ; (2019) 'Novel peptide nanoparticle-biased antagonist of CCR3 blocks eosinophil recruitment and airway hyperresponsiveness'. Journal of Allergy and Clinical Immunology, 143 (2). [DOI] [Full-Text] | |
2019 | Kim DY; Furuta GT; Nguyen N; Inage E; Masterson JC; (2019) 'Epithelial Claudin Proteins and Their Role in Gastrointestinal Diseases'. Journal of Pediatric Gastroenterology and Nutrition, 68 (5). [DOI] [Full-Text] | |
2018 | Wright BL; Nguyen N; Shim KP; Masterson JC; Jacobsen EA; Ochkur SI; Lee JJ; Furuta GT; (2018) 'Increased GATA-3 and T-bet expression in eosinophilic esophagitis versus gastroesophageal reflux disease'. Journal of Allergy and Clinical Immunology, . [DOI] [Full-Text] | |
2018 | Inage E; Furuta GT; Menard-Katcher C; Masterson JC; (2018) 'Eosinophilic esophagitis: pathophysiology and its clinical implications'. American Journal of Physiology - Gastrointestinal and Liver Physiology, 315 (5). [DOI] [Full-Text] | |
2017 | Nguyen N; Fernando SD; Biette KA; Hammer JA; Capocelli KE; Kitzenberg DA; Glover LE; Colgan SP; Furuta GT; Masterson JC; (2017) 'TGF-β1 alters esophageal epithelial barrier function by attenuation of claudin-7 in eosinophilic esophagitis'. Mucosal Immunology, . [DOI] [Full-Text] | |
2017 | Neudecker, V; Brodsky, KS; Clambey, ET; Schmidt, EP; Packard, TA; Davenport, B; Standiford, TJ; Weng, TT; Fletcher, AA; Barthel, L; Masterson, JC; Furuta, GT; Cai, CY; Blackburn, MR; Ginde, AA; Graner, MW; Janssen, WJ; Zemans, RL; Evans, CM; Burnham, EL; Homann, D; Moss, M; Kreth, S; Zacharowski, K; Henson, PM; Eltzschig, HK (2017) 'Neutrophil transfer of miR-223 to lung epithelial cells dampens acute lung injury in mice'. Science Translational Medicine, 9 . [DOI] [Full-Text] | |
2017 | Whelan KA; Merves JF; Giroux V; Tanaka K; Guo A; Chandramouleeswaran PM; Benitez AJ; Dods K; Que J; Masterson JC; Fernando SD; Godwin BC; Klein-Szanto AJ; Chikwava K; Ruchelli ED; Hamilton KE; Muir AB; Wang ML; Furuta GT; Falk GW; Spergel JM; Nakagawa H; (2017) 'Autophagy mediates epithelial cytoprotection in eosinophilic oesophagitis'. Gut, 66 (7). [DOI] [Full-Text] | |
2017 | Mark J; Fernando SD; Masterson JC; Pan Z; Capocelli KE; Furuta GT; de Zoeten EF; (2017) 'Clinical Implications of Pediatric Colonic Eosinophilia'. Journal of Pediatric Gastroenterology and Nutrition, . [DOI] [Full-Text] | |
2017 | McNamee, EN; Biette, KA; Hammer, J; Harris, R; Miyazawa, H; Lee, JJ; Furuta, GT; Masterson, JC (2017) 'Targeting granulocyte-macrophage colony-stimulating factor in epithelial and vascular remodeling in experimental eosinophilic esophagitis'. Allergy: European Journal of Allergy and Clinical Immunology, 72 :1232-1242. [DOI] [Full-Text] | |
2016 | Nguyen N; Furuta GT; Masterson JC; (2016) 'Deeper Than the Epithelium: Role of Matrix and Fibroblasts in Pediatric and Adult Eosinophilic Esophagitis'. Journal of Pediatric Gastroenterology and Nutrition, 63 (2). [DOI] [Full-Text] | |
2016 | Lynn TM; Molloy EL; Masterson JC; Glynn SF; Costello RW; Avdalovic MV; Schelegle ES; Miller LA; Hyde DM; O'Dea S; (2016) 'SMAD Signaling in the Airways of Healthy Rhesus Macaques versus Rhesus Macaques with Asthma Highlights a Relationship Between Inflammation and Bone Morphogenetic Proteins'. American Journal of Respiratory Cell and Molecular Biology, 54 (4). [DOI] [Full-Text] | |
2016 | Rosenberg HF; Masterson JC; Furuta GT; (2016) 'Eosinophils, probiotics, and the microbiome'. Journal Of Leukocyte Biology, 100 (5). [DOI] [Full-Text] | |
2015 | Capocelli KE; Fernando SD; Menard-Katcher C; Furuta GT; Masterson JC; Wartchow EP; (2015) 'Ultrastructural features of eosinophilic oesophagitis: impact of treatment on desmosomes'. Journal of Clinical Pathology, 68 (1). [DOI] [Full-Text] | |
2015 | McNamee EN; Masterson JC; Veny M; Collins CB; Jedlicka P; Byrne FR; Ng GY; Rivera-Nieves J; (2015) 'Chemokine receptor CCR7 regulates the intestinal TH1/TH17/Treg balance during Crohn's-like murine ileitis'. Journal Of Leukocyte Biology, 97 (6). [DOI] [Full-Text] | |
2015 | Masterson JC; McNamee EN; Fillon SA; Hosford L; Harris R; Fernando SD; Jedlicka P; Iwamoto R; Jacobsen E; Protheroe C; Eltzschig HK; Colgan SP; Arita M; Lee JJ; Furuta GT; (2015) 'Eosinophil-mediated signalling attenuates inflammatory responses in experimental colitis'. Gut, 64 (8). [DOI] [Full-Text] | |
2015 | Menard-Katcher C; Furuta GT; Masterson JC; (2015) 'Mucosal inflammation, esophageal eosinophilia, and celiac disease: a little pinch will have to do you'. Journal of Pediatric Gastroenterology and Nutrition, 60 (4). [DOI] [Full-Text] | |
2015 | Victorino F; Sojka DK; Brodsky KS; McNamee EN; Masterson JC; Homann D; Yokoyama WM; Eltzschig HK; Clambey ET; (2015) 'Tissue-Resident NK Cells Mediate Ischemic Kidney Injury and Are Not Depleted by Anti-Asialo-GM1 Antibody'. Journal of Immunology, 195 (10). [DOI] [Full-Text] | |
2015 | Masterson JC; Capocelli KE; Hosford L; Biette K; McNamee EN; de Zoeten EF; Harris R; Fernando SD; Jedlicka P; Protheroe C; Lee JJ; Furuta GT; (2015) 'Eosinophils and IL-33 Perpetuate Chronic Inflammation and Fibrosis in a Pediatric Population with Stricturing Crohn's Ileitis'. Inflammatory Bowel Diseases, 21 (10). [DOI] [Full-Text] | |
2015 | Aherne CM; Saeedi B; Collins CB; Masterson JC; McNamee EN; Perrenoud L; Rapp CR; Curtis VF; Bayless A; Fletcher A; Glover LE; Evans CM; Jedlicka P; Furuta GT; de Zoeten EF; Colgan SP; Eltzschig HK; (2015) 'Epithelial-specific A2B adenosine receptor signaling protects the colonic epithelial barrier during acute colitis'. Mucosal Immunology, 8 (6). [DOI] [Full-Text] | |
2015 | Harris JK; Fang R; Wagner BD; Choe HN; Kelly CJ; Schroeder S; Moore W; Stevens MJ; Yeckes A; Amsden K; Kagalwalla AF; Zalewski A; Hirano I; Gonsalves N; Henry LN; Masterson JC; Robertson CE; Leung DY; Pace NR; Ackerman SJ; Furuta GT; Fillon SA; (2015) 'Esophageal microbiome in eosinophilic esophagitis'. PLoS ONE, 10 (5). [DOI] [Full-Text] | |
2015 | Saeedi BJ; Kao DJ; Kitzenberg DA; Dobrinskikh E; Schwisow KD; Masterson JC; Kendrick AA; Kelly CJ; Bayless AJ; Kominsky DJ; Campbell EL; Kuhn KA; Furuta GT; Colgan SP; Glover LE; (2015) 'HIF-dependent regulation of claudin-1 is central to intestinal epithelial tight junction integrity'. Molecular Biology of the Cell, 26 (12). [DOI] [Full-Text] | |
2014 | Masterson JC; McNamee EN; Hosford L; Capocelli KE; Ruybal J; Fillon SA; Doyle AD; Eltzschig HK; Rustgi AK; Protheroe CA; Lee NA; Lee JJ; Furuta GT; (2014) 'Local hypersensitivity reaction in transgenic mice with squamous epithelial IL-5 overexpression provides a novel model of eosinophilic oesophagitis'. Gut, 63 (1). [DOI] [Full-Text] | |
2013 | Furuta GT; Kagalwalla AF; Lee JJ; Alumkal P; Maybruck BT; Fillon S; Masterson JC; Ochkur S; Protheroe C; Moore W; Pan Z; Amsden K; Robinson Z; Capocelli K; Mukkada V; Atkins D; Fleischer D; Hosford L; Kwatia MA; Schroeder S; Kelly C; Lovell M; Melin-Aldana H; Ackerman SJ; (2013) 'The oesophageal string test: a novel, minimally invasive method measures mucosal inflammation in eosinophilic oesophagitis'. Gut, 62 (10). [DOI] [Full-Text] | |
2013 | McNamee EN; Masterson JC; Jedlicka P; Collins CB; Williams IR; Rivera-Nieves J; (2013) 'Ectopic lymphoid tissue alters the chemokine gradient, increases lymphocyte retention and exacerbates murine ileitis'. Gut, 62 (1). [DOI] [Full-Text] | |
2013 | Brandon JL; Schroeder S; Furuta GT; Capocelli K; Masterson JC; Fenton LZ; (2013) 'CT imaging features of eosinophilic colitis in children'. Pediatric Radiology, 43 (6). [DOI] [Full-Text] | |
2013 | Schroeder S; Capocelli KE; Masterson JC; Harris R; Protheroe C; Lee JJ; Furuta GT; (2013) 'Effect of proton pump inhibitor on esophageal eosinophilia'. Journal of Pediatric Gastroenterology and Nutrition, 56 (2). [DOI] [Full-Text] | |
2013 | Schroeder S; Robinson ZD; Masterson JC; Hosford L; Moore W; Pan Z; Harris R; Souza RF; Spechler SJ; Fillon SA; Furuta GT; (2013) 'Esophageal human β-defensin expression in eosinophilic esophagitis'. Pediatric Research, 73 (5). [DOI] [Full-Text] | |
2012 | Kagalwalla AF; Akhtar N; Woodruff SA; Rea BA; Masterson JC; Mukkada V; Parashette KR; Du J; Fillon S; Protheroe CA; Lee JJ; Amsden K; Melin-Aldana H; Capocelli KE; Furuta GT; Ackerman SJ; (2012) 'Eosinophilic esophagitis: epithelial mesenchymal transition contributes to esophageal remodeling and reverses with treatment'. Journal of Allergy and Clinical Immunology, 129 (5). [DOI] [Full-Text] | |
2012 | Fillon SA; Harris JK; Wagner BD; Kelly CJ; Stevens MJ; Moore W; Fang R; Schroeder S; Masterson JC; Robertson CE; Pace NR; Ackerman SJ; Furuta GT; (2012) 'Novel device to sample the esophageal microbiome--the esophageal string test'. PLoS ONE, 7 (9). [DOI] [Full-Text] | |
2012 | Schroeder S; Fleischer DM; Masterson JC; Gelfand E; Furuta GT; Atkins D; (2012) 'Successful treatment of eosinophilic esophagitis with ciclesonide'. Journal of Allergy and Clinical Immunology, 129 (5). [DOI] [Full-Text] | |
2012 | Aherne CM; Collins CB; Masterson JC; Tizzano M; Boyle TA; Westrich JA; Parnes JA; Furuta GT; Rivera-Nieves J; Eltzschig HK; (2012) 'Neuronal guidance molecule netrin-1 attenuates inflammatory cell trafficking during acute experimental colitis'. Gut, 61 (5). [DOI] [Full-Text] | |
2011 | Masterson JC; McNamee EN; Jedlicka P; Fillon S; Ruybal J; Hosford L; Rivera-Nieves J; Lee JJ; Furuta GT; (2011) 'CCR3 Blockade Attenuates Eosinophilic Ileitis and Associated Remodeling'. American Journal of Pathology, 179 (5). [DOI] [Full-Text] | |
2011 | Masterson, JC; Molloy, EL; Gilbert, JL; McCormack, N; Adams, A; O'Dea, S (2011) 'Bone morphogenetic protein signalling in airway epithelial cells during regeneration'. Cellular Signalling, 23 :398-406. [DOI] [Full-Text] | |
2011 | Masterson JC; Furuta GT; Lee JJ; (2011) 'Update on clinical and immunological features of eosinophilic gastrointestinal diseases'. Current Opinion in Gastroenterology, 27 (6). [DOI] [Full-Text] | |
2011 | McNamee EN; Masterson JC; Jedlicka P; McManus M; Grenz A; Collins CB; Nold MF; Nold-Petry C; Bufler P; Dinarello CA; Rivera-Nieves J; (2011) 'Interleukin 37 expression protects mice from colitis'. Proceedings of the National Academy of Sciences of the United States of America, 108 (40). [DOI] [Full-Text] | |
2011 | Woodruff SA; Masterson JC; Fillon S; Robinson ZD; Furuta GT; (2011) 'Role of eosinophils in inflammatory bowel and gastrointestinal diseases'. Journal of Pediatric Gastroenterology and Nutrition, 52 (6). [DOI] [Full-Text] | |
2010 | McNamee EN; Wermers JD; Masterson JC; Collins CB; Lebsack MD; Fillon S; Robinson ZD; Grenawalt J; Lee JJ; Jedlicka P; Furuta GT; Rivera-Nieves J; (2010) 'Novel model of TH2-polarized chronic ileitis: the SAMP1 mouse'. Inflammatory Bowel Diseases, 16 (5). [DOI] [Full-Text] | |
2008 | Molloy, EL; Adams, A; Moore, JB; Masterson, JC; Madrigal-Estebas, L; Mahon, BP; O'Dea, S (2008) 'BMP4 induces an epithelial-mesenchymal transition-like response in adult airway epithelial cells'. Growth Factors, 26 :12-22. [DOI] [Full-Text] | |
2007 | Masterson J; O'Dea S; (2007) 'Posttranslational truncation of E-cadherin and significance for tumour progression'. Cells Tissues Organs, 185 (1-3). [DOI] [Full-Text] | |
2007 | Masterson, JC; O'Dea, S (2007) '5-Bromo-2-deoxyuridine activates DNA damage signalling responses and induces a senescence-like phenotype in p16-null lung cancer cells'. Anti-Cancer Drugs, 18 :1053-1068. [Full-Text] |
Letters
Year | Publication | |
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[Letters] [DOI] |
Certain data included herein are derived from the © Web of Science (2024) of Clarivate. All rights reserved.
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Teaching Interests
I teach Molecular Biology of the Cell (BI210) and Applied Immunology (BI418/BI606).
I am the MAP Academic Advisor for the Department of Biology.