Dr Özlem Sarikaya Bayram
Biography
Research and Academic Background:
Dr. Sarikaya Bayram is an SFI-IRC Pathways Principal Investigator, currently leading the Sustainable Future Foods and Food Safety Research Group at Maynooth University. Her research focuses on development of sustainable future foods and the epigenetic regulation of mycotoxins, which are significant contaminants in food that affect human and animal health. Her impactful work on food safety was highlighted in Bridge Magazine at Maynooth University in December 2022. Furthermore, Dr. Sarikaya Bayram is interested in nutrigenetics and the development of nutraceuticals as future functional foods.
Educational Qualifications:
Dr. Sarikaya Bayram earned her Ph.D. (Dr.rer.nat) summa cum laude from the Göttingen Graduate Centre for Neurosciences, Biophysics, and Molecular Biosciences, through a collaboration between Georg August University and the Max Planck Institute in Germany. This achievement was made possible by securing the highly competitive Excellence Ph.D. Scholarship. Dr. Sarikaya Bayram was also honored with the Elisabeth Gateff Best Ph.D. in Genetics Award by the German Genetics Society, in recognition of her groundbreaking discovery on a methyltransferase complex that epigenetically regulates mycotoxin biosynthesis in Aspergillus nidulans, published in Developmental Cell.
Postdoctoral and Industry Experience:
Following her doctoral studies, Dr. Sarikaya Bayram secured an IRC Postdoctoral Fellowship to conduct research at Maynooth University, focusing on Aspergillus fumigatus, an opportunistic human pathogen with a high mortality rate. Her contributions during this period include significant publications on the regulation of gliotoxin production and pathogen sporulation control. Additionally, Dr. Sarikaya Bayram investigated host-pathogen interactions, specifically between bone marrow-derived macrophages and Aspergillus fumigatus spores, providing valuable insights into pathogen pathogenicity and mammalian defense mechanisms.
Dr. Sarikaya Bayram has also gained extensive industry experience in the pharmaceutical sector, specializing in biologics testing for diabetes and breast cancer treatments. This role has equipped her with practical insights into the application of biotechnological advancements in healthcare.
Publications and Contributions:
Dr. Sarikaya Bayram is the author of the book Functional Whole Food Plant-Based Nutrition for Longevity, now in its second edition and published in Turkish by Nobel Scientific Press. The book addresses the prevention of epidemic diseases such as diabetes and obesity through functional food choices, reflecting Dr. Sarikaya Bayram's commitment to public health and nutrition education. She is also a functional medicine health coach, supporting people to transform their lives by focusing on the root causes of disease and personalized nutrition based on the genetic backgrounds of individuals.
Research Impact:
With over 1,000 citations to her name, Dr. Sarikaya Bayram's research has made a significant impact on the scientific community. Her work continues to influence the fields of food safety, sustainable future foods, epigenetics, mycology, and nutrition, positioning her as a leading expert.
Future Directions:
As an Assistant Professor in Nutrition and Health, Dr. Sarikaya Bayram aims to continue advancing research in food safety, sustainable future functional foods, and nutraceuticals. Her interdisciplinary approach, combining expertise in epigenetics, biology, and nutrition, will contribute to groundbreaking advancements in disease prevention and public health .
Dr. Sarikaya Bayram is dedicated to mentoring the next generation of scientists, fostering an environment of innovation and excellence in her research group. Her vision is to create a healthier future through science-based future nutrition, nutrigenetics and epigenetic research, aligning with the mission and values of Maynooth University.
Research Interests
- Prevention of mycotoxins from food sources.
- Epigenetic regulation of fungal bioactive molecules.
- Functional future foods.
- Fungal enzymes for food processing and production.
- Human nutrition
- Fermentation technologies.
Research Projects
Peer Reviewed Journal
| Year | Publication | |
|---|---|---|
| 2023 | Alves de Castro, P; Figueiredo Pinzan, C; Dos Reis, TF; Valero, C; Van Rhijn, N; Menegatti, C; de Freitas Migliorini, IL; Bromley, M; Fleming, AB; Traynor, AM; Sarikaya-Bayram, Ö; Bayram, Ö; Malavazi, I; Ebel, F; Barbosa, JCJ; Fill, T; Pupo, MT; Goldman, GH (2023) 'Aspergillus fumigatus mitogen-activated protein kinase MpkA is involved in gliotoxin production and self-protection'. Nature Communications, 15 (1). [DOI] | |
| 2023 | Borges, BM; Ramos, RBC; Preite, NW; Kaminski, VL; Alves de Castro, P; Camacho, M; Maximo, MF; Fill, TP; Calich, VLG; Traynor, AM; Sarikaya-Bayram, Ö; Doyle, S; Bayram, Ö; de Campos, CBL; Zelanis, A; Goldman, GH; Loures, FV (2023) 'Transcriptional profiling of a fungal granuloma reveals a low metabolic activity of Paracoccidioides brasiliensis yeasts and an actively regulated host immune response'. Frontiers in Cellular and Infection Microbiology, 13 . [DOI] | |
| 2023 | Sarikaya Bayram, Ö; Bayram, Ö (2023) 'An Anatomy of Fungal Eye: Fungal Photoreceptors and Signalling Mechanisms'. Journal Of Fungi, 5 (9):1-22. [DOI] | |
| 2023 | Karahoda, B; Pfannenstiel, BT; Sarikaya-Bayram, Ö; Dong, Z; Ho Wong, K; Fleming, AB; Keller, NP; Bayram, Ö (2023) 'The KdmB-EcoA-RpdA-SntB (KERS) chromatin regulatory complex controls development, secondary metabolism and pathogenicity in Aspergillus flavus'. Fungal genetics and biology : FG & B, 169 . [DOI] [Full-Text] | |
| 2023 | Bauer, I; Sarikaya Bayram, Ö; Bayram, Ö (2023) 'The use of immunoaffinity purification approaches coupled with LC-MS/MS offers a powerful strategy to identify protein complexes in filamentous fungi'. Essays in Biochemistry, 67 (5). [DOI] | |
| 2023 | Traynor, A.M., Sarikaya-Bayram, Ö., Bayram, Ö., Calera J.A., and Doyle, S. (2023) 'Proteomic dissection of role of GliZ in gliotoxin biosynthesis in Aspergillus fumigatus'. Fungal Genetics and Biology, 166 (103795). [Link] [DOI] [Full-Text] | |
| 2022 | Sarikaya Bayram Ö; Bayram Ö; Karahoda B; Meister C; Köhler AM; Thieme S; Elramli N; Frawley D; McGowan J; Fitzpatrick DA; Schmitt K; de Assis LJ; Valerius O; Goldman GH; Braus GH; (2022) 'F-box receptor mediated control of substrate stability and subcellular location organizes cellular development of Aspergillus nidulans'. PLoS Genetics, 18 (12). [DOI] [Full-Text] | |
| 2022 | Karahoda B; Pardeshi L; Ulas M; Dong Z; Shirgaonkar N; Guo S; Wang F; Tan K; Sarikaya-Bayram Ö; Bauer I; Dowling P; Fleming AB; Pfannenstiel BT; Luciano-Rosario D; Berger H; Graessle S; Alhussain MM; Strauss J; Keller NP; Wong KH; Bayram Ö; (2022) 'The KdmB-EcoA-RpdA-SntB chromatin complex binds regulatory genes and coordinates fungal development with mycotoxin synthesis'. Nucleic Acids Research, . [DOI] [Full-Text] | |
| 2020 | Bauer I.; Gross S.; Merschak P.; Kremser L.; Karahoda B.; Bayram Ö.S.; Abt B.; Binder U.; Gsaller F.; Lindner H.; Bayram Ö.; Brosch G.; Graessle S. (2020) 'RcLS2F – A Novel Fungal Class 1 KDAC Co-repressor Complex in Aspergillus nidulans'. Frontiers in Microbiology, 11 . [DOI] [Full-Text] | |
| 2019 | Bayram Ö.; Dettmann A.; Karahoda B.; Moloney N.; Ormsby T.; McGowan J.; Cea-Sánchez S.; Miralles-Durán A.; Brancini G.; Luque E.; Fitzpatrick D.; Cánovas D.; Corrochano L.; Doyle S.; Selker E.; Seiler S.; Bayram Ö. (2019) 'Control of development, secondary metabolism and light-dependent carotenoid biosynthesis by the velvet complex of Neurospora crassa'. Journal of Genetics, 212 (3):691-710. [DOI] [Full-Text] | |
| 2019 | Elramli N; Karahoda B; Sarikaya-Bayram Ö; Frawley D; Ulas M; Oakley CE; Oakley BR; Seiler S; Bayram Ö; (2019) 'Assembly of a heptameric STRIPAK complex is required for coordination of light-dependent multicellular fungal development with secondary metabolism in Aspergillus nidulans'. PLoS Genetics, 15 (3). [DOI] [Full-Text] | |
| 2018 | de Assis L.; Ulas M.; Ries L.; El Ramli N.; Sarikaya-Bayram O.; Braus G.; Bayram O.; Goldman G. (2018) 'Regulation of Aspergillus nidulans CreA-mediated catabolite repression by the F-Box proteins Fbx23 and Fbx47'. mBio, 9 (3). [DOI] [Full-Text] | |
| 2018 | Frawley D.; Karahoda B.; Sarikaya Bayram Ö.; Bayram Ö. (2018) 'The HamE scaffold positively regulates MpkB phosphorylation to promote development and secondary metabolism in Aspergillus nidulans'. Scientific Reports, 8 (1). [DOI] [Full-Text] | |
| 2017 | Valsecchi I; Sarikaya-Bayram Ö; Wong Sak Hoi J; Muszkieta L; Gibbons J; Prevost MC; Mallet A; Krijnse-Locker J; Ibrahim-Granet O; Mouyna I; Carr P; Bromley M; Aimanianda V; Yu JH; Rokas A; Braus GH; Saveanu C; Bayram Ö; Latgé JP; (2017) 'MybA, a transcription factor involved in conidiation and conidial viability of the human pathogen Aspergillus fumigatus'. Molecular Microbiology, . [DOI] [Full-Text] | |
| 2017 | Sarikaya Bayram Ö; Latgé JP; Bayram Ö; (2017) 'MybA, a new player driving survival of the conidium of the human pathogen Aspergillus fumigatus'. Current Genetics, . [DOI] [Full-Text] | |
| 2016 | Manzanares-Miralles, L; Sarikaya-Bayram, O; Smith, EB; Dolan, SK; Bayram, O; Jones, GW; Doyle, S (2016) 'Quantitative proteomics reveals the mechanism and consequence of gliotoxin-mediated dysregulation of the methionine cycle in Aspergillus niger'. JOURNAL OF PROTEOMICS, 131 :149-162. [DOI] [Full-Text] | |
| 2014 | Sarikaya-Bayram O.; Bayram O.; Feussner K.; Kim J.; Kim H.; Kaever A.; Feussner I.; Chae K.; Han D.; Han K.; Braus G. (2014) 'Membrane-bound methyltransferase complex VapA-VipC-VapB guides epigenetic control of fungal development'. Developmental Cell, 29 (4):406-420. [DOI] [Full-Text] | |
| 2013 | Suzuki S; Sarikaya Bayram Ö; Bayram Ö; Braus GH; (2013) 'conF and conJ contribute to conidia germination and stress response in the filamentous fungus Aspergillus nidulans'. Fungal Genetics and Biology, 56 . [DOI] [Full-Text] | |
| 2012 | Bayram O; Bayram OS; Valerius O; Jöhnk B; Braus GH; (2012) 'Identification of protein complexes from filamentous fungi with tandem affinity purification'. Methods in molecular biology (Clifton, N.J.), 944 . [DOI] | |
| 2012 | Bayram Ö; Bayram ÖS; Ahmed YL; Maruyama J; Valerius O; Rizzoli SO; Ficner R; Irniger S; Braus GH; (2012) 'The Aspergillus nidulans MAPK module AnSte11-Ste50-Ste7-Fus3 controls development and secondary metabolism'. PLoS Genetics, 8 (7). [DOI] [Full-Text] | |
| 2010 | Sarikaya Bayram O; Bayram O; Valerius O; Park HS; Irniger S; Gerke J; Ni M; Han KH; Yu JH; Braus GH; (2010) 'LaeA control of velvet family regulatory proteins for light-dependent development and fungal cell-type specificity'. PLoS Genetics, 6 (12). [DOI] [Full-Text] |
Reviews
| Year | Publication | |
|---|---|---|
| 2015 | Sarikaya-Bayram, O; Palmer, JM; Keller, N; Braus, GH; Bayram, O (2015) One Juliet and four Romeos: VeA and its methyltransferases. LAUSANNE: [Reviews] [DOI] |
Book Chapter
| Year | Publication | |
|---|---|---|
| 2016 | Irniger S, Sarikaya-Bayram O, Bayram O (2016) 'Fungal MAP-Kinase-Mediated Regulatory Pathways' In: Biochemistry and Molecular Biology, 3rd Edition The Mycota III. Switzerland : Springer. [DOI] |